
==== Front
Res Sq
ResearchSquare
Research Square
2693-5015
American Journal Experts

10.21203/rs.3.rs-4908040/v1
10.21203/rs.3.rs-4908040
preprint
1
Article
Frailty, Physical Function Impairment and Pulmonary Function in Aging Men with and without HIV from the Multicenter AIDS Cohort Study (MACS)
Abdo Mona
Kunisaki Ken M
Morris Alison
Stosor Valentina
Chang Dong
D’Souza Gypsyamber
Crothers Kristina
Abdel-Maksoud Madiha
DiGuiseppi Carolyn
Brown Todd T
MaWhinney Samantha
Erlandson Kristine M
10 9 2024
rs.3.rs-4908040https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
https://www.researchsquare.com/article/rs-4908040/v1
nihpp-rs4908040v1.pdf
Abstract

Background People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments. Methods Associations of frailty and physical function (gait speed [m/sec], grip strength [kg]) with pulmonary function (< 80% predicted diffusing capacity for carbon monoxide [DL CO ] and forced expiratory volume [FEV 1 ]) 3 years later were modeled; age, HIV status, and smoking were assessed as effect modifiers. Results Among1,024 men, (54% PAWH, 10% frail, 51% pre-frail), mean (SD) age = 53 (12) years, cumulative smoking = 12 (19) pack-years, gait speed = 1.1 (0.2) m/sec, and grip strength = 36.6 (9.2) kg. Frailty, pre-frailty, and weak grip strength were associated with higher odds of subsequent impaired DL CO and FEV 1 . Slow gait speed was associated with higher odds of DL CO impairment but not FEV 1 . No statistically significant modifications were found. Conclusion Interventions to improve physical function may help preserve pulmonary function.
==== Body
pmc
