
==== Front
Cureus
Cureus
2168-8184
Cureus
2168-8184
Cureus Palo Alto (CA)

10.7759/cureus.67521
Endocrinology/Diabetes/Metabolism
Pathology
Dermatology
Solitary Superficial Angiomyxoma in an Uncommon Location: A Case Report and Literature Review
Muacevic Alexander
Adler John R
Oprea Alexandra Denisa 1
Margaritescu Irina 2
Beiu Cristina 3
Radaschin Diana 4
Popescu Marius 5
Popa Liliana Gabriela 3
1 Dermatology, Elias Emergency University Hospital, Bucharest, ROU
2 Dermatopathology, OncoTeam Diagnostic, Bucharest, ROU
3 Dermatology, Carol Davila University of Medicine and Pharmacy, Elias Emergency University Hospital, Bucharest, ROU
4 Dermatology, Saint Parascheva Infectious Disease Clinical Hospital, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, Galati, ROU
5 Physical Medicine and Rehabilitation, Carol Davila University of Medicine and Pharmacy, Elias Emergency University Hospital, Bucharest, ROU
Diana Radaschin dianaradaschin@yahoo.com
22 8 2024
8 2024
16 8 e6752122 8 2024
Copyright © 2024, Oprea et al.
2024
Oprea et al.
https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This article is available from https://www.cureus.com/articles/281114-solitary-superficial-angiomyxoma-in-an-uncommon-location-a-case-report-and-literature-review
Superficial angiomyxoma (SAM) is a rare, benign, and slow-growing soft tissue tumor with a tendency for frequent local recurrence. Most SAMs are solitary and sporadic. However, multiple SAMs, particularly on the external ear or eyelids, may be the initial or only sign of the Carney complex, an autosomal dominant syndrome that impacts various organs, including the heart, breasts, and skin, and is linked to endocrine hyperactivity. To ensure an accurate diagnosis, a comprehensive patient interview, physical examination, and laboratory tests, including endocrine-specific markers and imaging studies, are essential. Due to the high risk of recurrence, especially in large, encapsulated lesions, complete surgical excision is the preferred treatment approach. We present a case of a 24-year-old female with SAM on the shoulder, review the relevant literature, and discuss the pathogenesis and appropriate management of such cases.

mohs surgery
spindle-shaped cells
myxoma
carney complex
superficial angiomyxoma
==== Body
pmcIntroduction

Superficial angiomyxoma (SAM), first described in 1985, is a relatively under-recognized cutaneous tumor. In 1988, Allen et al. classified angiomyxomas into two subtypes: aggressive and superficial [1]. Aggressive angiomyxoma, a rare myxoid neoplasm, predominantly affects the genital, perineal, and pelvic regions in young women, suggesting estrogen’s role in its growth [2]. In contrast, SAM can occur at any age, with a slight male predominance, and is most common in the third to fourth decade of life. Pediatric cases, particularly in the genital area, are rare [2]. Angiomyofibroblastoma, added later to the classification, is now considered a third subtype of angiomyxoma [3].

SAM typically appears as a slow-growing, asymptomatic solitary nodule or polypoid lesion less than 5 cm in diameter, often with a multilobular or multinodular form. It most frequently arises on the trunk, head and neck, and lower extremities and rarely affects the breasts or eyelids.

The presence of multiple SAMs should prompt consideration of the Carney complex, a rare syndrome featuring cutaneous myxomas, mammary myxomas, cardiac myxomas, lentigines, endocrine hyperactivity, and psammomatous melanotic schwannoma. SAM may be the earliest or sole manifestation of this syndrome.

Immunohistochemical studies indicate that loss of PRKAR1A protein expression is involved in SAM development [4]. This loss may result from genetic defects, epigenetic abnormalities (such as DNA hypermethylation), or protein-related deviations (like posttranscriptional modifications). Thus, PRKAR1A immunostaining is a crucial diagnostic tool, particularly for distinguishing SAM from other myxoid lesions in small biopsy specimens [4].

Given the high rate of local recurrence (30-40% after incomplete resection) [5], complete surgical excision is the treatment of choice. Mohs micrographic surgery may be considered for difficult-to-treat areas where preserving tissue for cosmetic reasons is essential.

Case presentation

A 24-year-old female, with no significant personal or familial medical history, presented to our clinic with a slowly enlarging nodule on her left shoulder that had been present for one year. The skin examination revealed a well-defined, skin-colored nodule with fine superficial vessels on the surface, measuring 7 cm in diameter, surrounded by normal skin (Figure 1). The nodule was tender upon palpation.

Figure 1 Well-defined, skin-colored nodule with fine superficial vessels on the surface, measuring 7 cm in diameter. The nodule is located on the left shoulder and is surrounded by normal skin.

An excisional biopsy was performed (Figure 2), and the histopathologic examination revealed a well-defined, encapsulated tumor mass. The tumor exhibited monomorphous spindle-shaped cells with small nuclei, prominent nucleoli, reduced cytoplasm, and thin-walled blood vessels embedded in a myxoid stroma. No pleomorphism, nuclear atypia, or necrosis was observed (Figure 3). Tumor cells stained intensely positive for CD34 and were only focally positive for actin, but negative for SOX10, calponin, and MUC4. The Ki-67 proliferation index was 10-12%. To prevent recurrence, the patient underwent a wide surgical excision.

Figure 2 Macroscopic appearance of a partially encapsulated, highly vascular cutaneous tumor. The tumor displays a smooth surface, bosselated contours, and a pink color, measuring 5 × 4 cm.

Figure 3 H&E stain.

The H&E stain reveals a well-defined, encapsulated tumor mass with monomorphous spindle-shaped cells, small nuclei, reduced cytoplasm, and thin-walled blood vessels embedded in abundant myxoid stroma. The tumor shows no pleomorphism or nuclear atypia (H&E, A: 12.5×, B: 25×, and C: 200×).

Due to the particularities of the case - a large tumor, more than 5 cm in diameter, in contact with bone affecting a young female patient - she was referred to an endocrinologist, and additional laboratory analyses were conducted to rule out endocrine hyperactivity. Levels of intact parathormone, vitamin D, prolactin, growth hormone, insulin-like growth factor 1, and thyroid-stimulating hormone were within normal limits. Additionally, cardiac and thyroid ultrasounds did not reveal any pathological findings. Consequently, the Carney complex was ruled out.

Discussion

Systematic literature review

To better understand the epidemiology and progression of SAM, we conducted a review of the medical literature. We searched for the term “solitary angiomyxoma” using PubMed and Google Scholar, identifying 88 relevant publications (Table 1) [1-88]. We analyzed data from these studies, focusing on lesion location, age at diagnosis, patient gender, and recurrence rates during follow-up. The review followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines (Figure 4) [89]. Out of 123 records identified, 35 were review articles and were excluded. The remaining 88 records, detailing SAM cases, were included in both the qualitative and quantitative analyses.

Table 1 SAM cases reported in the medical literature.

SAM, superficial angiomyxoma; UA, unavailable information

No.	Study	Number of cases	Location	Age of patients at diagnosis	Gender	Course	
1	Sharma et al. [6]	54	19 on the trunk, especially on the back; 18 on the lower limbs; 10 on the head and neck region; 7 on the arm	7 to 91 years (mean, 55 years)	31 F, 23 M	1 tumor recurred after 3 years	
2	Baranov et al. [7]	40	All tumors are located on the breasts, 9 of them on the nipple-areola complex	14 to 72 years (mean, 40 years)	22 F, 18 M	1 tumor recurred after incomplete excision	
3	Calonje et al. [8]	39	17 on the trunk, 14 on the head and neck, and 7 on the lower limbs	Birth to 82 years (median, 45.5 years)	25 M, 14	8 tumors recurred, 4 of them twice	
4	Allen et al. [1]	30 tumors in 28 patients	11 on the trunk, 10 on the lower extremity, 5 on the head or neck, and 4 on the arm	4 to 78 years (mean, 39 years)	16 M, 12 F	8 tumors recurred once 1 patient developed a new SAM	
5	Neumann et al. [4]	28	UA	5 to 87 years (mean 49.7 years)	UA	UA	
6	Fetsch et al. [9]	17	M: all lesions were located on the scrotum; F: 6 on the labium, 4 on the vulva, 2 on the groin, and 1 on the mons pubis	M: 18 to 55 years (mean: 39 years), F: 15 to 33 years (mean: 21 years)	4 M, 13 F	3 tumors recurred after 8 months, 7 years, and 20 years	
7	Perret et al. [10]	4	Face lower limb subungual subungual	55, 61, 18, 53	F, F, M, M	UA	
8	Nakayama et al. [11]	1	Inguinal region	64	M	UA	
9	Velanovich [12]	1	Inguinal region	2	M	UA	
10	Teixeira-De-Magalhães and Pardal-De-Oliveira [13]	1	Larynx	UA	UA	Recurred	
11	Izquierdo et al. [14]	1	Areola	49	F	UA	
12	Ustun et al. [15]	1	Vulva	42	F	UA	
13	Bedlow et al. [16]	1	Scalp	Congenital	F	UA	
14	Chen et al. [17]	1	Buccal mucosa	19	M	UA	
15	Vella et al. [3]	1	Epididymis	50	M	UA	
16	Gardner [18]	1	Floor of the mouth	69	F	UA	
17	Yamamoto et al. [19]	1	Lower limb	19	M	UA	
18	Rodríguez-Vázquez et al. [20]	1	Preauricular region	34	F	UA	
19	Yuen et al [21]	1	Eyelid	47	M	UA	
20	Okada et al. [22]	1	Vulva	3	F	UA	
21	Misago et al. [23]	1	Digit	59	F	UA	
22	Wu and Lin [24]	1	Neck	26	M	UA	
23	Kim et al. [25]	1	Vulva	26	F	UA	
24	Satter [26]	1	Midback	35	M	UA	
25	Pérez Tato et al. [27]	1	Trunk	51	M	UA	
26	Meer and Beavon [28]	1	Buccal mucosa	37	F	UA	
27	Khadilkar et al. [29]	1	External ear	20	F	UA	
28	Nakamura and Tokura [30]	1	Scrotum	4	M	UA	
29	Rosado Rodríguez et al. [31]	1	Parotid region	61	M	UA	
30	Zhu et al. [32]	1	Vulva	27	F	UA	
31	Toth et al. [33]	1	Retropharyngeal	28	M	UA	
32	Qian et al. [34]	1	Toe	60	M	UA	
33	Ali et al. [35]	1	Eyelid	77	M	Recurred after 8 years	
34	Falidas et al. [36]	1	Subungual	45	M	UA	
35	Basak et al. [37]	1	Vulva	39	F	Recurred 18 months after incomplete resection	
36	Nishio et al. [38]	1	First web space of the hand	39	M	UA	
37	Sibley et al. [39]	1	Scalp	9	M	UA	
38	Zhu et al. [40]	1	Vulva	27	F	UA	
39	Ravindra et al. [41]	1	Upper posterior alveolar mucosa	30	M	UA	
40	Diniz et al. [42]	1	Gluteal region	12	F	UA	
41	Lee et al. [5]	1	Scrotum	56	M	UA	
42	Wang et al. [43]	1	Scrotum	25	M	UA	
43	Kahn et al. [44]	1	Nasal dorsum	28	M	UA	
44	Kura et al. [45]	1	Digit	UA	UA	UA	
45	Green et al. [46]	1	UA	33	M	UA	
46	Bhat et al. [47]	1	Digit (thumb)	70	M	UA	
47	Zhang and Xu [48]	1	UA	UA	UA	UA	
48	Lemtibbet et al. [49]	1	Plantar region	60	F	UA	
49	Ozdemir et al. [50]	1	Vulva	26	F	UA	
50	Victoria Martínez et al. [51]	1	Nipple	28	F	UA	
51	Shukla et al. [52]	1	Parotid region	congenital	F	UA	
52	Lee et al. [53]	1	Vulva	60	F	UA	
53	Abarzúa-Araya et al. [54]	1	Lower back	72	M	UA	
54	Aberdein et al. [55]	2	Scalp, lower back	63, 47	M, M	UA	
55	Anehosur et al. [56]	1	Buccal vestibule	32	M	UA	
56	Singhota et al. [57]	2	Lower lip palate	47, 58	F, M	UA	
57	Wang et al. [58]	2 tumors in 1 patient	Penis	18	M	1 tumor recurred 2 years after incomplete excision	
58	Imen et al. [59]	1	Vagina	40	F	UA	
59	Bajpai et al. [60]	1	Palate	29	M	UA	
60	Hamzelou et al. [61]	1	Plantar region	25	M	UA	
61	O'Flynn O'Brien et al. [62]	1	Vulva	7	F	UA	
62	Iwashita et al. [63]	1	Nipple	39	F	UA	
63	Chen et al. [64]	1	Vulva	50	F	UA	
64	Hafeez et al. [65]	1	Vulva	1.5	F	UA	
65	Hwang et al. [66]	1	Posterior neck	6	M	UA	
66	Amores-Martín et al. [67]	1	Lower limb	62	M	UA	
67	Chen et al. [68]	1	Nasal vestibule	53	F	UA	
68	Hosapatna Basavarajappa et al. [69]	1	Vulva	25	F	UA	
69	Morimoto et al. [70]	1	Gingiva	15	F	UA	
70	Fotiadou et al. [71]	1	Tongue	70	F	UA	
71	Dubin et al. [72]	1	Breast	16	F	UA	
72	Xu et al. [73]	1	Scrotum	N/A	M	UA	
73	Chen et al. [74]	1	Eye socket	23	M	UA	
74	Meng et al. [75]	1	Breast	25	F	UA	
75	Yan et al. [76]	1	Perineum	42	M	UA	
76	Chijiiwa et al. [77]	1	Wrist	71	M	UA	
77	Ros Briones et al. [2]	1	Vulva	congenital	F	UA	
78	Hirai et al. [78]	1	Soft palate	41	M	UA	
79	Navea et al. [79]	1	Popliteal fossa	61	M	UA	
80	Tonape and Sv [80]	1	Axilla	42	M	UA	
81	Park et al. [81]	1	Nipple	12	F	UA	
82	Singh et al. [82]	1	Ear pinna	24	F	UA	
83	Navitski et al. [83]	2	Vulva	28, 42	F, F	UA	
84	Mehrotra et al. [84]	2	Vulva	38, 17	F, F	UA	
85	Yun et al. [85]	1	Eyelid	29	F	UA	
86	Bembem et al. [86]	1	Lower limb	14	F	UA	
87	Lee et al. [87]	1	Vulva	13	F	UA	
88	Quatresooz et al. [88]	1	Submammary region	40	F	UA	

Figure 4 PRISMA flow diagram.

Of the 123 records identified through database searching, 35 were review articles and were excluded. The remaining 88 records, detailing SAM cases, were included in the qualitative and quantitative synthesis.

PRISMA, Preferred Reporting Items for Systematic reviews and Meta-Analyses; SAM, superficial angiomyxoma

Out of the 88 publications, seven presented case series with four to 54 patients [1,4,6-10], while the remaining were case reports. In total, 298 SAMs have been reported in 295 patients. Cases were reported across all ages, including three congenital SAMs in female patients located on the scalp, parotid region, and vulva. The oldest patient was 91 years old, with a mean age of 37.9 years. Of the 295 patients, 150 were female, resulting in a female-to-male ratio of 1.03.

Tumor locations included 53 cases (17.7%) on the trunk, particularly the lower back; 46 cases (15.4%) on the breasts, with 13 (4.3%) involving the nipple-areola region; 44 cases (14.7%) in the head and neck region, including three on the eyelid, one in the eye socket, two on the external ear, three in the parotid region, and three on the scalp; 41 cases (13.7%) on the lower limbs, including two on the soles (0.6%); 37 cases (12.4%) in the genital area, with tumors in the vulva (27 cases), vagina (one case), scrotum (eight cases), penis (one case), and epididymis (one case). Less common sites included the upper limbs (13 cases or 4.3%), fingers/toes (seven cases or 2.3%, including three subungual SAMs), and the inguinal region (four cases or 1.3%). SAMs also developed in the oral mucosa (10 cases or 0.3%), retropharyngeal area (one case or 0.3%), larynx (one case or 0.3%), and nasal vestibule (one case or 0.3%) (Figure 5).

Figure 5 Distribution of SAM cases reported in the literature according to tumor location.

SAM, superficial angiomyxoma

The majority of patients underwent complete surgical excision, although Mohs micrographic surgery, shave biopsy, and laser treatment were also used. Follow-up intervals varied from six months to two years. Recurrence occurred in 25 tumors, often after incomplete excision, with four tumors recurring twice. The time to recurrence ranged from eight months to 20 years.

SAM is a rare, slow-growing benign soft tissue tumor with a significant risk of local recurrence. Diagnosis relies on clinical presentation and histopathologic features, though additional diagnostic methods can be helpful. Dermoscopy may reveal the “red planet sign” - reddish translucent globules with fine superficial vessels [46]. Ultrasonography can assist in the initial diagnosis by showing an irregular, heterogeneously echogenic cystic and solid lesion with multiple thin echogenic septa and micro-lobulated margins [5,64]. CT scans show similar heterogeneity with variable enhancement, while MRI typically shows a homogeneous tumor with fluid-like signal intensity and variable heterogeneous enhancement on contrast-enhanced images [5].

SAM can mimic various benign and malignant tumors, necessitating careful clinical and histopathological differential diagnosis. Differential diagnoses include aggressive angiomyxoma, myxoid neurofibroma (SOX10 positive), soft tissue myxoma (characterized by prominent myxoid matrix), nodular fasciitis (with spindle stellate cells and positive calponin staining) [86,90], and low-grade myxofibrosarcoma (with abundant mucoid stroma, an arborizing capillary network, lipoblasts, and MUC4 positivity) [86,90]. Myxoid dermatofibrosarcoma, which shows spindle cells with glassy eosinophilic cytoplasm, vesicular nuclei, and focal CD34 positivity, should also be considered [86,90].

Despite its benign nature, SAM’s high recurrence rate post-excision and potential for rare muscle infiltration underscore the importance of Mohs micrographic surgery for small tumors to ensure clear margins. Larger, encapsulated lesions often require traditional excision. Long-term follow-up is essential, as recurrences may appear many years after the initial resection.

Conclusions

Due to its rarity and subtle histological features, SAM necessitates thorough evaluation by experienced pathologists and careful correlation with clinical findings (age, gender, location, and symptoms) for an accurate diagnosis. Additional diagnostic tools, such as dermoscopy, ultrasonography, CT, and MRI, can aid in differential diagnosis. A complete surgical excision is crucial for achieving a favorable aesthetic and functional outcome, given the tumor’s significant potential for local recurrence, which can occur even decades after the initial diagnosis. We aim to raise awareness about this uncommon tumor and emphasize the importance of close monitoring for affected patients.

The publication of this paper was supported by the Carol Davila University of Medicine and Pharmacy through the Institutional Open Access Program.

Disclosures

Author Contributions

Human subjects: Consent was obtained or waived by all participants in this study.

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following:

Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work.

Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work.

Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Concept and design:  Alexandra Denisa Oprea, Liliana Gabriela Popa

Drafting of the manuscript:  Alexandra Denisa Oprea, Liliana Gabriela Popa

Critical review of the manuscript for important intellectual content:  Liliana Gabriela Popa, Irina Margaritescu, Marius Popescu, Cristina Beiu, Diana Radaschin

Supervision:  Liliana Gabriela Popa, Irina Margaritescu, Marius Popescu

Acquisition, analysis, or interpretation of data:  Irina Margaritescu, Marius Popescu, Cristina Beiu, Diana Radaschin
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46 Myxoid stroma and delicate vasculature of a superficial angiomyxoma give rise to the red planet sign Dermatol Online J Green M Logemann N Sulit DJ 13030 13035 20 2014 https://pubmed.ncbi.nlm.nih.gov/25244175/
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50 A case of vulvar superficial angiomyxoma: a rare clinical entity J Obstet Gynaecol Ozdemir M Uzun I Karahasanoglu A Ceylan C 683 684 36 2016 26925850
51 Superficial angiomyxoma of the nipple: a case report of an infrequent cutaneous tumour Dermatol Online J Victoria Martínez AM Sánchez Carazo JL Alegre de Miquel V 13030 13039 22 2016 https://pubmed.ncbi.nlm.nih.gov/28329589/
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53 Superficial angiomyxoma of the vulva in a postmenopausal woman: a case report and review of literature J Menopausal Med Lee SH Cho YJ Han M Bae JW Park JW Oh SR Kim S 180 183 22 2016 28119899
54 Superficial angiomyxoma of the skin Dermatol Pract Concept Abarzúa-Araya A Lallas A Piana S Longo C Moscarella E Argenziano G 47 49 6 2016
55 Mohs micrographic surgery for the treatment of superficial angiomyxoma Dermatol Surg Aberdein G Veitch D Perrett C 1014 1016 42 2016 27467232
56 Intraoral superficial angiomyxoma: a case report J Maxillofac Oral Surg Anehosur V Adirajaiah S Ghosh R 371 374 15 2016 27408472
57 Two rare cases of superficial angiomyxoma in the oral cavity Br J Oral Maxillofac Surg Singhota S Lam M Gahir DS Malins T 107 108 55 2017 27289342
58 Superficial angiomyxoma of penis: a case report of a 6-year follow-up Asian J Androl Wang YC Li XM Zhong GP Xing Z Wang ZP 262 263 19 2017 26975493
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60 Superficial angiomyxoma of palate J Coll Physicians Surg Pak Bajpai M Pardhe N Vijay P 794 27 2017 https://pubmed.ncbi.nlm.nih.gov/29185414/ 29185414
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62 A rare case of vulvar superficial angiomyxoma in a pediatric patient J Pediatr Adolesc Gynecol O'Flynn O'Brien KL Cortes-Santiago N Patil NM Bercaw-Pratt JL 727 729 33 2020 32739529
63 Superficial angiomyxoma of the nipple in a japanese woman: a case report and review of literature Int J Surg Pathol Iwashita W Kurabayashi A Tanaka C Naganuma S Kawamura T Aki F Furihata M 683 687 28 2020 32204631
64 Sonographic findings in superficial angiomyxoma of the vulva in a perimenopausal female J Med Ultrasound Chen L Chen L Wang JL Hu C Liu ZX Yuan XC He JX 202 204 27 2019 31867195
65 Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression Histopathology Hafeez F Krakowski AC Lian CG Nazarian RM Maleszewski JJ 1001 1003 80 2022 34532875
66 Superficial angiomyxoma of the posterior neck Arch Craniofac Surg Hwang YJ Lee HW Lee IS Jung SG Lee HK 62 65 22 2021 http://33714255 33714255
67 Superficial angiomyxoma: dermoscopic findings [Article in English, Spanish] Actas Dermosifiliogr (Engl Ed) Amores-Martín E de Los Ángeles Sola Casas M Fernández-Figueras MT 2021
68 Superficial angiomyxoma in nasal vestibule: a case report [Article in Chinese] Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Chen X Ma S Li Y Xu B Liu Z 556 558 36 2022 35822387
69 Giant superficial angiomyxoma of the vulva - a bizarre presentation J Obstet Gynaecol Can Hosapatna Basavarajappa D Gainder S Srinivasan R 853 44 2022 35589522
70 Rapidly growing superficial angiomyxoma in mandibular gingiva: a case report and literature review Head Neck Pathol Morimoto M Takano M Sato T Kitamura T Makino S 956 961 16 2022 35397068
71 Large superficial angiomyxoma of the tongue causing dysphagia Ear Nose Throat J Fotiadou S Garefis K Chatziavramidis A Konstantinidis I Massa E Markou K Konstantinidis I 1455613211068004 2021
72 Superficial angiomyxoma of the breast in a 16-year-old girl without carney's complex: a case report Breast J Dubin I Mortazavi S Yu T Riahi IR Baker JL 887 889 27 2021 34862711
73 Ultrasonic features of superficial angiomyxoma in the scrotum: a case image J Clin Ultrasound Xu Y Duan Y Zhou H Chen H Yan W 1273 1275 51 2023 37219372
74 Imaging findings of superficial angiomyxoma in the eye socket Clin Case Rep Chen G Liu W Cao Y Guo X Xie Y 0 11 2023
75 Superficial angiomyxoma of the breast in a 25-year-old woman without Carney complex Asian J Surg Meng T Yin H Chen L Zhao Q 2461 2463 46 2023 36822938
76 Giant superficial angiomyxoma of the male perineum: a case report Front Surg Yan S Zou Y Liao X 1010050 9 2022 36684192
77 Superficial angiomyxoma of the wrist: case report and literature review In Vivo Chijiiwa Y Nagano T Nishio J 503 505 37 2023 36593012
78 A rare case of solitary intraoral superficial angiomyxoma arising in the soft palate J Oral Sci Hirai H Kayamori K Noji R Kuroshima T Ikeda T Harada H 69 71 65 2023 36385052
79 Superficial angiomyxoma in an uncommon area: a case report Cureus Navea OV Navea MB De la Fuente R 0 15 2023
80 Superficial angiomyxoma of axilla: a case report Cureus Tonape T Sv S 0 15 2023
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82 Solitary superficial angiomyxoma of the ear pinna: a diagnostic dilemma with a review of literature Arch Clin Cases Singh A Rawat S Kumar G Singh US Sagar M 128 132 10 2023 37767055
83 A tale of two vulvar angiomyxomas: two cases and review of literature Gynecol Oncol Rep Navitski A Adams L Brzezinska BN 101204 47 2023 37304973
84 Large superficial angiomyxoma of the vulva-report of two cases with varied clinical presentation Indian Dermatol Online J Mehrotra K Bhandari M Khullar G Sharma S 605 607 12 2021 34430472
85 Rare case of isolated superficial angiomyxoma of the eyelid Korean J Ophthalmol Yun YI Lee KS Khwarg SI Kim N 262 264 34 2020 32495538
86 Cyto-histo correlation of a very rare tumor: superficial angiomyxoma J Cytol Bembem K Jaiswal A Singh M Verma N Jain S Bhat A 230 232 34 2017 29118482
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