
==== Front
Front Immunol
Front Immunol
Front. Immunol.
Frontiers in Immunology
1664-3224
Frontiers Media S.A.

10.3389/fimmu.2024.1467807
Immunology
Correction
Corrigendum: Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency
Rucci Francesca 1

Poliani Pietro Luigi 2
Caraffi Stefano 1
Paganini Tiziana 3
Fontana Elena 2
Giliani Silvia 3

Alt Frederick W. 4

Notarangelo Luigi Daniele 1 *

1 Division of Immunology and The Manton Center for Orphan Disease Research, Children’s Hospital Boston, Boston, MA, United States
2 Department of Pathology, University of Brescia, Brescia, Italy
3 “Angelo Nocivelli” Institute for Molecular Medicine and Department of Pediatrics, University of Brescia, Brescia, Italy
4 Howard Hughes Medical Institute, Children’s Hospital, Immune Disease Institute and Harvard Medical School, Boston, MA, United States
Edited and Reviewed by: Menno C. van Zelm, Monash University, Australia

*Correspondence: Luigi Daniele Notarangelo, luigi.notarangelo@childrens.harvard.edu
05 9 2024
2024
05 9 2024
15 146780720 7 2024
09 8 2024
Copyright © 2024 Rucci, Poliani, Caraffi, Paganini, Fontana, Giliani, Alt and Notarangelo
2024
Rucci, Poliani, Caraffi, Paganini, Fontana, Giliani, Alt and Notarangelo
https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
A Corrigendum on Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency By Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW and Notarangelo LD (2011). Front. Immun. 2:15. doi: 10.3389/fimmu.2011.00015 severe combined immunodeficiency
recombination-activating gene 1
DNA ligase 4
thymic epithelial cells
thymus
dendritic cells
Aire
regulatory T cells
section-in-acceptancePrimary Immunodeficiencies
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pmcIn the published article, there was an error in Figure 5 as published.

“The insets within the right upper and middle panels showing a higher magnification of the AIRE immunostaining have been corrected. In the original panels, there was a mistake in placing the original insets from a higher magnification image.”

The corrected Figure 5 and its caption appear below.

Figure 5 Maturation of medullary thymic epithelial cells (mTECs) in wild-type (WT), Lig4 R/R, and Rag1 S/S mice. Mature mTECs from WT mice express claudin-4 (Cld4), Ulex europaeus agglutinin 1 (UEA-1) and Aire (upper panels). Insets highlight fully mature mTECs showing immunoreactivity (IR) for Cld4 and the characteristic granular dot-like Aire positivity in the nuclei. Thymuses from Lig4 R/R mice show residual presence of mTECs that reach full maturation with positivity for UEA-1, Cld4, and Aire expression (middle panels). Loss of corticomedullary demarcation (CMD) with impaired maturation of mTECs was observed in the thymuses from the Rag1 S/S mice in which only rare UEA-1 IR cells but no mature Cld4+ and Aire+ cells were found (lower panels). IR staining: brown. All panels are from 20× original magnification; insets are from 40× original magnification. One representative example of five mice analyzed per each strain.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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