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Endoscopy
Endoscopy
10.1055/s-00000012
Endoscopy
Endoscopy
0013-726X
1438-8812
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany

38959974
10.1055/a-2337-7551
E-Videos-2024-04-4951-EV
E-Videos
First report of opportunistic screening for nasopharyngeal carcinoma by gastroscopy
Huang Jialiang
Li Qinkai Dr.
Wu Wei MD
1 105860 Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, China
Correspondence Wei Wu, MD Department of Gastroenterology, Second Affiliated Hospital of Soochow University1055 Sanxiang RoadSuzhou City, Jiangsu ProvinceP.R. China93757495@qq.com
03 7 2024
12 2024
1 7 2024
56 Suppl 1 E571E571
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
2024
The Author(s).
https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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pmc A 45-year-old woman presented at our hospital with epigastric pain. Gastroscopy was undertaken, but before the gastroscope was inserted into her esophagus, her nasopharynx was examined. This examination revealed a 1.8-cm lesion ( Video 1Video 1 ) near the pharyngeal opening of the eustachian (pharyngotympanic) tube on the right side. Blue light imaging and linked color imaging showed irregular microvasculature on the surface of the lesion ( Fig. 1Fig. 1 ). Pathological analysis identified squamous cell nonkeratinized carcinoma, with positive immunohistochemistry for P40 ( Fig. 2Fig. 2 a ) and CK5/6 ( Fig. 2Fig. 2 b ). The Ki-67 index was 50%. Subsequently, the patient was diagnosed with nasopharyngeal carcinoma. This is the first report of opportunistic screening for nasopharyngeal carcinoma using gastroscopy.

Fig. 1 Fig. 1a Gastroscopic observation of squamous cell nonkeratinized carcinoma in the nasopharynx of a 45-year-old woman (dashed lines outline the lesion): a white light imaging; b blue light imaging; c linked color imaging.

Fig. 2 Fig. 2a Positive immunohistochemical staining: a P40 (× 100); b CK5/6 (× 100).

Observation of the nasopharynx by gastroscopy.

Video 1

Video 1

The nasopharynx is easy to access using a gastroscope. The gastroscope provides sufficient illumination and a high-quality visual field, and is equipped with electronic staining and magnification functions, which contribute to early detection of changes in the nasopharyngeal mucosal surface. It is particularly sensitive for detecting surface roughness, localized hyperplasia, and color changes, and enables any nasopharyngeal lesions identified to be biopsied. Opportunistic screening can enhance the detection rate of nasopharyngeal carcinoma, particularly in regions with a high incidence of this cancer.

Endoscopy_UCTN_Code_TTT_1AO_2AB

Conflict of Interest The authors declare that they have no conflict of interest.
