
==== Front
JAAD Case Rep
JAAD Case Rep
JAAD Case Reports
2352-5126
Elsevier

S2352-5126(24)00287-X
10.1016/j.jdcr.2024.07.014
Case Report
Undiluted 25% intralesional sodium thiosulfate in the management of dystrophic calcinosis cutis
Benandi Katherine BBA, MPH ab
Sieving Devon BS a
Bumgardner Amy MD a
Wolf Kristin MD kwolf@complete-derm.com
a∗
a Complete Dermatology, Conroe, Texas
b John Sealy School of Medicine, University of Texas Medical Branch, Galveston, Texas
∗ Correspondence to: Kristin Wolf, MD, Complete Dermatology, 508 Medical Center Blvd, Ste 380, Conroe, TX 77304. kwolf@complete-derm.com
03 8 2024
10 2024
03 8 2024
52 810
© 2024 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.
2024
American Academy of Dermatology, Inc.
https://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Key words

calcifying disorders
calcinosis cutis
dermatomyositis
sodium thiosulfate
Abbreviation used

STS sodium thiosulfate
==== Body
pmcIntroduction

Calcinosis cutis is a multifactorial condition defined by insoluble calcium salt deposition in cutaneous and subcutaneous tissue. There are 5 etiology-dependent subtypes associated with this condition, including dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Dystrophic calcinosis cutis, the most common subtype, is associated with autoimmune connective tissue disease, including dermatomyositis.1

Management of calcinosis cutis is often challenging, as treatments are subtype dependent and vary with factors such as size and severity. It is particularly difficult to treat dystrophic calcinosis cutis that is secondary to autoimmune connective tissue disease. The primary goal is often related to improving quality of life, rather than total resolution of the lesion.2 Treatment options include various pharmacologic therapies as well as surgical resection, although it remains unclear which is most effective.

One emerging pharmacologic option for dystrophic calcinosis cutis is topical or intralesional sodium thiosulfate (STS). Existing reports of intralesional STS therapy have demonstrated variable success rates. In a double-blind placebo-controlled pilot study where patients underwent 12 weeks of monthly injections of STS 40 mg/mL, only 1 of the 4 patients who completed therapy had a positive result.3 Another study in Germany reported 100% total resolution in 13 patients with calcinosis cutis with lesions ≤2 cm treated with 250 mg/mL (undiluted) STS.4 The same study cited a failure to fully resolve any lesions >2 cm when using this method.4 It is unknown, however, whether these patients experienced any symptomatic improvements, especially those related to quality of life.

Adverse effects associated with intralesional STS include injection site pain/irritation and ulceration, which may be exacerbated at higher concentrations.5 This often results in treatment at diluted concentrations, which may be less efficacious, especially when treating larger lesions. This case describes a patient with a dystrophic calcinosis cutis lesion who experienced significant improvement with a series of undiluted intralesional STS injections.

Case report

A man in his early 50s with a history of dermatomyositis presented with an 11 × 9 cm indurated, white cutaneous, painful nodule on lateral aspect of the upper portion of his left thigh (Fig 1). Subsequent biopsy revealed large fragments of calcification of the subcutis without evidence of vasculitis or malignant/atypical features, consistent with a diagnosis of dystrophic calcinosis cutis secondary to dermatomyositis. Over the course of a year, the severity of the lesion fluctuated with dermatomyositis control, as the patient attempted various therapeutics including azathioprine and mycophenolate mofetil.Fig 1 Calcinosis cutis lesion measuring 11 × 9 cm at initial presentation. Estimated margins of the lesion are marked by the encircled area.

After lack of improvement with mycophenolate mofetil and increasing discomfort associated with the lesion, the patient elected to begin intralesional STS therapy. Of note, the patient did not have renal impairment prompting possible dose adjustment. Before all STS treatments, the area was infiltrated with lidocaine 1% solution to make injections more tolerable. The first treatment consisted of 2 different concentrations, which served to compare both efficacy and dose-dependent side effects. The anterior aspect of the lesion was injected with 1 mL of 150 mg/mL, whereas the posterior aspect was injected with 0.3 mL of 250 mg/mL, undiluted STS. The patient denied significant differences in pain upon injection with different concentrations. At 2 week follow-up, he did not show significant improvement, but reported no adverse effects with either concentration. Because the patient was able to tolerate the higher concentration well, all subsequent treatments were performed with 250 mg/mL undiluted STS, in an attempt to maximize therapeutic benefit.

The patient underwent 11 additional treatments in 2 to 6 week intervals over the span of 13 months, ranging from 2 to 6 mL of undiluted STS. He tolerated each treatment well with no ulceration or other adverse effects noted. The patient first reported mild improvement after his second treatment, noting the lesion had both softened and decreased in size at 3 week follow-up. He continued to progress throughout treatment duration, ultimately reporting less pain and discomfort associated with the lesion. The final size of the lesion was 5 × 4 cm (Fig 2).Fig 2 Calcinosis cutis lesion measuring 5 × 4 cm after 12 intralesional sodium thiosulfate treatments over a 13 month period. Estimated margins of the lesion are marked by the encircled area.

Discussion

This is the first report of significant improvement of a large, dystrophic calcinosis cutis lesion from undiluted 25% STS therapy. As such, it highlights the importance of reporting qualitative data such as symptomatic improvement and enhanced quality of life as measures of success in treating this condition. Prior studies, which only assess success by total resolution, may fail to recognize what would otherwise be classified as substantial improvement for a patient with this complex condition. This was the case for our patient, who noted significant reduction of pain and discomfort associated with his lesion, despite lack of total clearance.

Although we lack data on efficacy for lower concentrations of STS versus undiluted STS, our findings highlight the potential clinical utility of undiluted STS in the management of dystrophic calcinosis cutis. Additionally, the patient’s lack of severe injection site pain or ulceration warrant further investigation into the potential for routine use of higher concentrations of STS in this condition. If it proves to be equally tolerable and more efficacious than previously attempted concentrations, patients may achieve faster therapeutic effects or heightened levels of overall improvement.

Conflicts of interest

None disclosed.

Funding sources: None.

Patient consent: The authors attest that they have obtained written consent from patient/s, their legal guardian/s or person/s with legal authority, for their photographs and medical information to be published in print and online and with the understanding that this information may be publicly available. Patient consent forms were not provided to the journal but are retained by the authors to be made available upon request.

IRB approval status: Not applicable.
==== Refs
References

1 Walsh J.S. Fairley J.A. Calcifying disorders of the skin J Am Acad Dermatol 33 5 Pt 1 1995 693 710 10.1016/0190-9622(95)91803-5 7593766
2 Balin S.J. Wetter D.A. Andersen L.K. Davis M.D.P. Calcinosis cutis occurring in association with autoimmune connective tissue disease: the Mayo Clinic experience with 78 patients, 1996-2009 Arch Dermatol 148 4 2012 455 462 10.1001/archdermatol.2011.2052 22184719
3 Winter A.R. Klager S. Truong R. Foley A. Sami N. Weinstein D. Efficacy of intralesional sodium thiosulfate for the treatment of dystrophic calcinosis cutis: a double-blind, placebo-controlled pilot study JAAD Int 1 2 2020 114 120 10.1016/j.jdin.2020.07.002 34409331
4 Howard R.M. Smith G.P. Treatment of calcinosis cutis with sodium thiosulfate therapy J Am Acad Dermatol 83 5 2020 1518 1520 10.1016/j.jaad.2020.06.996 32622148
5 Baumgartner-Nielsen J. Olesen A.B. Treatment of skin calcifications with intra-lesional injection of sodium thiosulphate: a case series Acta Derm Venereol 96 2 2016 257 258 10.2340/00015555-2206 26258586
