
==== Front
bioRxiv
BIORXIV
bioRxiv
2692-8205
Cold Spring Harbor Laboratory

10.1101/2024.08.22.609111
preprint
1
Article
StrIDR: a database of intrinsically disordered regions of proteins with experimentally resolved structures
Majila Kartik http://orcid.org/0009-0006-3190-7977

Viswanath Shruthi http://orcid.org/0000-0002-9061-8407

26 8 2024
2024.08.22.609111https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
http://biorxiv.org/lookup/doi/10.1101/2024.08.22.609111
nihpp-2024.08.22.609111.pdf
Abstract

Motivation

Intrinsically disordered regions (IDRs) of proteins exist as an ensemble of conformations, and not as a single structure. Existing databases contain extensive, experimentally derived annotations of intrinsic disorder for millions of proteins at the sequence level. However, only a tiny fraction of these IDRs are associated with an experimentally determined protein structure. Moreover, even if a structure exists, parts of the disordered regions may still be unresolved.

Results

Here we organize Str uctures of I ntrinsically D isordered R egions (StrIDR), a database of IDRs confirmed via experimental or homology-based evidence, resolved in experimentally determined structures. The database can provide useful insights into the dynamics, folding, and interactions of IDRs. It can also facilitate computational studies on IDRs, such as those using molecular dynamics simulations and/or machine learning.

Availability

StrIDR is available at https://isblab.ncbs.res.in/stridr . The web UI allows for downloading PDB structures and SIFTS mappings of individual entries. Additionally, the entire database can be downloaded in a JSON format. The source code for creating and updating the database is available at https://github.com/isblab/stridr .
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