
==== Front
Res Sq
ResearchSquare
Research Square
2693-5015
American Journal Experts

39184073
10.21203/rs.3.rs-4579052/v1
10.21203/rs.3.rs-4579052
preprint
1
Article
Immune Infiltration Correlates with Transcriptomic Subtypes in Primary ER+ Invasive Lobular Breast Cancer
Oesterreich Steffi
Chen Fangyuan
Onkar Sayali
Zou Jian
Li Yujia
Arbore Haley
Maley Sai
Tseng George https://orcid.org/0000-0002-5447-1014

Lucas Peter
Bruno Tullia
Vignali Dario
Foldi Julia https://orcid.org/0000-0002-7504-867X

Balic Marija
Lee Adrian https://orcid.org/0000-0001-9917-514X

13 8 2024
rs.3.rs-4579052https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
https://www.researchsquare.com/article/rs-4579052/v1
nihpp-rs4579052v1.pdf
Abstract

Understanding interplay of breast cancer and microenvironment is critical. Here, we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER+/HER2- invasive lobular breast cancers. The proliferative subtype associated with increased immune infiltration especially by immunosuppressive regulatory T-cells and macrophages. We also defined a TAM-Low signature, which associated with lower infiltration of proliferative, pro-inflammatory TAM, and improved outcome in patients with ER+ tumors.
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