
==== Front
Animal Model Exp Med
Animal Model Exp Med
10.1002/(ISSN)2576-2095
AME2
Animal Models and Experimental Medicine
2096-5451
2576-2095
John Wiley and Sons Inc. Hoboken

10.1002/ame2.12492
AME212492
Cover Picture
Cover Picture
Cover Picture
02 9 2024
8 2024
7 4 10.1002/ame2.v7.4 Themed Issue: Study on Cardiovascular and Cerebrovascular Diseases ii
© 2024 The Chinese Association for Laboratory Animal Sciences
https://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

The cover image is based on the article ‘Cucurbitacins mitigate vascular neointimal hyperplasia by suppressing cyclin A2 expression and inhibiting VSMC proliferation’ (DOI: 10.1002/ame2.12457) reported by Ruqiang Yuan, Lei Qian, Hu Xu and Weijing Yun. Restenosis is characterized by the proliferation of vascular smooth muscle cells (VSMCs) and is commonly seen after percutaneous angioplasty, posing a serious threat to health. The continuous proliferation of VSMCs is like a high‐speed racing car, with the rotating gears of the cell cycle. Cucurbitacins extracted from Cucumis melo L. (CuECs) including cucurbitacin B (CuB), play the role of “whistleblowers” when danger is detected, and promptly “brake” to halt the cell cycle progression, thus avoiding greater danger. Therefore, CuECs, especially CuB, may have the potential to prevent restenosis.

source-schema-version-number2.0
cover-dateAugust 2024
details-of-publishers-convertorConverter:WILEY_ML3GV2_TO_JATSPMC version:6.4.8 mode:remove_FC converted:03.09.2024
==== Body
pmc
