
==== Front
ArXiv
ArXiv
arxiv
ArXiv
2331-8422
Cornell University

arXiv:2405.15905v1
2405.15905
1
preprint
Article
Tangent space functional reconfigurations in individuals at risk for alcohol use disorder
Moghaddam Mahdi
Dzemidzic Mario
Guerrero Daniel
Liu Mintao
Alessi Jonathan
Plawecki Martin H.
Harezlak Jaroslaw
Kareken David
Goñi Joaquín
24 5 2024
arXiv:2405.15905v1https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
http://arxiv.org/abs/2405.15905v1
nihpp-2405.15905v1.pdf
Human brain function dynamically adjusts to ever-changing stimuli from the external environment. Studies characterizing brain functional reconfiguration are nevertheless scarce. Here we present a principled mathematical framework to quantify brain functional reconfiguration when engaging and disengaging from a stop signal task (SST). We apply tangent space projection (a Riemannian geometry mapping technique) to transform functional connectomes (FCs) and quantify functional reconfiguration using the correlation distance of the resulting tangent-FCs. Our goal was to compare functional reconfigurations in individuals at risk for alcohol use disorder (AUD). We hypothesized that functional reconfigurations when transitioning in/from a task would be influenced by family history of alcohol use disorder (FHA) and other AUD risk factors. Multilinear regression model results showed that engaging and disengaging functional reconfiguration were driven by different AUD risk factors. Functional reconfiguration when engaging in the SST was negatively associated with recent drinking. When disengaging from the SST, however, functional reconfiguration was negatively associated with FHA. In both models, several other factors contributed to the explanation of functional reconfiguration. This study demonstrates that tangent-FCs can characterize task-induced functional reconfiguration, and that it is related to AUD risk.

29 pages, 9 Figures, 2 Tables, 3 Supplementary Figures, 1 Supplementary Table
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pmc
