PMID- 10660046
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20200310
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 100
IP  - 2
DP  - 2000 Jan 21
TI  - OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and 
      Olf signaling pathways.
PG  - 229-40
AB  - We have identified the 30-zinc finger protein OAZ as a DNA-binding factor that
      associates with Smads in response to BMP2, forming a complex that
      transcriptionally activates the homeobox regulator of Xenopus mesoderm and neural
      development, Xvent-2. OAZ contains a BMP signaling module formed by two clusters 
      of fingers that bind Smads and the Xvent-2 BMP response element, respectively.
      Previously implicated as a transcriptional partner of Olf-1/EBF in olfactory
      epithelium and lymphocyte development in the rat, OAZ fulfills this role through 
      clusters of fingers that are separate from the BMP signaling module. The mutually
      exclusive use of OAZ by the BMP-Smad and Olf pathways illustrates the dual role
      of a multi-zinc finger protein in signal transduction during development.
FAU - Hata, A
AU  - Hata A
AD  - Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering
      Cancer Center, New York, New York 10021, USA.
FAU - Seoane, J
AU  - Seoane J
FAU - Lagna, G
AU  - Lagna G
FAU - Montalvo, E
AU  - Montalvo E
FAU - Hemmati-Brivanlou, A
AU  - Hemmati-Brivanlou A
FAU - Massague, J
AU  - Massague J
LA  - eng
SI  - GENBANK/AF221712
GR  - CA34610/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (BABAM2 protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (EBF1 protein, human)
RN  - 0 (Ebf1 protein, rat)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proteins)
RN  - 0 (SMAD2 protein, human)
RN  - 0 (SMAD3 protein, human)
RN  - 0 (Smad Proteins)
RN  - 0 (Smad2 Protein)
RN  - 0 (Smad2 protein, Xenopus)
RN  - 0 (Smad2 protein, rat)
RN  - 0 (Smad3 Protein)
RN  - 0 (Smad3 protein, rat)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
RN  - 0 (ZNF423 protein, Xenopus)
RN  - 0 (ebf2 protein, Xenopus)
RN  - 0 (madh3 protein, Xenopus)
RN  - 0 (ornithine decarboxylase antizyme)
RN  - 0 (ventx1.2 protein, Xenopus)
RN  - 0 (ventx2.1 protein, Xenopus)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Bone Morphogenetic Proteins/*genetics/metabolism
MH  - COS Cells
MH  - Cell Nucleus/chemistry
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/analysis/*genetics/metabolism/*physiology
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Genes, Reporter
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Lac Operon
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/metabolism
MH  - Oocytes/physiology
MH  - Protein Binding/physiology
MH  - Proteins
MH  - Rats
MH  - Signal Transduction/*physiology
MH  - Smad Proteins
MH  - Smad2 Protein
MH  - Smad3 Protein
MH  - Trans-Activators/*physiology
MH  - Transcription Factors/analysis/*genetics/metabolism/*physiology
MH  - Transcription, Genetic/physiology
MH  - Xenopus
MH  - Xenopus Proteins/analysis/*genetics/metabolism/*physiology
MH  - Yeasts/genetics
MH  - Zinc Fingers/*genetics
EDAT- 2000/02/05 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/02/05 09:00
PHST- 2000/02/05 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/02/05 09:00 [entrez]
AID - S0092-8674(00)81561-5 [pii]
AID - 10.1016/s0092-8674(00)81561-5 [doi]
PST - ppublish
SO  - Cell. 2000 Jan 21;100(2):229-40. doi: 10.1016/s0092-8674(00)81561-5.