PMID- 10657303
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 287
IP  - 5454
DP  - 2000 Feb 4
TI  - A subclass of Ras proteins that regulate the degradation of IkappaB.
PG  - 869-73
AB  - Small guanosine triphosphatases, typified by the mammalian Ras proteins, play
      major roles in the regulation of numerous cellular pathways. A subclass of
      evolutionarily conserved Ras-like proteins was identified, members of which
      differ from other Ras proteins in containing amino acids at positions 12 and 61
      that are similar to those present in the oncogenic forms of Ras. These proteins, 
      kappaB-Ras1 and kappaB-Ras2, interact with the PEST domains of IkappaBalpha and
      IkappaBbeta [inhibitors of the transcription factor nuclear factor kappa B
      (NF-kappaB)] and decrease their rate of degradation. In cells, kappaB-Ras
      proteins are associated only with NF-kappaB:IkappaBbeta complexes and therefore
      may provide an explanation for the slower rate of degradation of IkappaBbeta
      compared with IkappaBalpha.
FAU - Fenwick, C
AU  - Fenwick C
AD  - Section of Immunobiology and Department of Molecular Biophysics and Biochemistry,
      Howard Hughes Medical Institute, Yale University School of Medicine, New Haven,
      CT 06510, USA.
FAU - Na, S Y
AU  - Na SY
FAU - Voll, R E
AU  - Voll RE
FAU - Zhong, H
AU  - Zhong H
FAU - Im, S Y
AU  - Im SY
FAU - Lee, J W
AU  - Lee JW
FAU - Ghosh, S
AU  - Ghosh S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (I-kappa B Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Transcription Factor RelA)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Cell Line
MH  - Guanosine Triphosphate/metabolism
MH  - Humans
MH  - I-kappa B Proteins/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-kappa B/metabolism
MH  - Phosphorylation
MH  - Recombinant Fusion Proteins/chemistry/metabolism
MH  - Signal Transduction
MH  - Transcription Factor RelA
MH  - Transfection
MH  - Tumor Necrosis Factor-alpha/metabolism/pharmacology
MH  - Two-Hybrid System Techniques
MH  - ras Proteins/chemistry/*metabolism
EDAT- 2000/02/05 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/05 09:00
PHST- 2000/02/05 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/05 09:00 [entrez]
AID - 8215 [pii]
AID - 10.1126/science.287.5454.869 [doi]
PST - ppublish
SO  - Science. 2000 Feb 4;287(5454):869-73. doi: 10.1126/science.287.5454.869.