PMID- 10657001
OWN - NLM
STAT- MEDLINE
DCOM- 20000324
LR  - 20191024
IS  - 0952-5041 (Print)
IS  - 0952-5041 (Linking)
VI  - 24
IP  - 1
DP  - 2000 Feb
TI  - Identification of two new nonclassical members of the rat prolactin family.
PG  - 95-108
AB  - The prolactin (PRL) family is comprised of a group of hormones/cytokines that are
      expressed in the anterior pituitary, uterus, and placenta. These proteins
      participate in the control of maternal and fetal adaptations to pregnancy. In
      this report, we have identified two new nonclassical members of the rat PRL
      family through a search of the National Center for Biotechnology Information
      dbEST database. The cDNAs were sequenced and their corresponding mRNAs
      characterized. Overall, the rat cDNAs showed considerable structural similarities
      with mouse proliferin-related protein (PLF-RP) and prolactin-like protein-F
      (PLP-F), consistent with their classification as rat homologs for PLF-RP and
      PLP-F. The expression of both cytokines/hormones was restricted to the placenta. 
      The intraplacental sites of PLF-RP and PLP-F synthesis differed in the rat and
      the mouse. In the mouse, PLF-RP was expressed in the trophoblast giant cell layer
      of the midgestation chorioallantoic and choriovitelline placentas and, during
      later gestation, in the trophoblast giant cell and spongiotrophoblast layers
      within the junctional zone of the mouse chorioallantoic placenta. In contrast, in
      the rat, PLF-RP was first expressed in the primordium of the chorioallantoic
      placenta (ectoplacental cone region) and, later, exclusively within the labyrinth
      zone of the chorioallantoic placenta. In the mouse, PLP-F is an exclusive product
      of the spongiotrophoblast layer, whereas in the rat, trophoblast giant cells were
      found to be the major source of PLP-F, with a lesser contribution from
      spongiotrophoblast cells late in gestation. In summary, we have established the
      presence of PLF-RP and PLP-F in the rat.
FAU - Sahgal, N
AU  - Sahgal N
AD  - Department of Pediatrics, University of Kansas Medical Center, Kansas City,
      Kansas 66160, USA. nsahgal@kumc.edu
FAU - Knipp, G T
AU  - Knipp GT
FAU - Liu, B
AU  - Liu B
FAU - Chapman, B M
AU  - Chapman BM
FAU - Dai, G
AU  - Dai G
FAU - Soares, M J
AU  - Soares MJ
LA  - eng
GR  - HD02528/HD/NICHD NIH HHS/United States
GR  - HD20676/HD/NICHD NIH HHS/United States
GR  - HD29797/HD/NICHD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (DNA, Complementary)
RN  - 0 (Plfr protein, mouse)
RN  - 0 (Plfr protein, rat)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (RNA, Messenger)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cell Line
MH  - DNA, Complementary
MH  - Female
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - Pregnancy Proteins/genetics
MH  - Prolactin/genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sequence Homology, Amino Acid
EDAT- 2000/02/05 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/02/05 09:00
PHST- 2000/02/05 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/02/05 09:00 [entrez]
AID - JME00851 [pii]
AID - 10.1677/jme.0.0240095 [doi]
PST - ppublish
SO  - J Mol Endocrinol. 2000 Feb;24(1):95-108. doi: 10.1677/jme.0.0240095.