PMID- 10655587
OWN - NLM
STAT- MEDLINE
DCOM- 20000320
LR  - 20161124
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 2
IP  - 2
DP  - 2000 Feb
TI  - The transcription factor snail is a repressor of E-cadherin gene expression in
      epithelial tumour cells.
PG  - 84-9
AB  - The adhesion protein E-cadherin plays a central part in the process of epithelial
      morphogenesis. Expression of this protein is downregulated during the acquisition
      of metastatic potential at late stages of epithelial tumour progression. There is
      evidence for a transcriptional blockage of E-cadherin gene expression in this
      process. Here we show that the transcription factor Snail, which is expressed by 
      fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to
      three E-boxes present in the human E-cadherin promoter and represses
      transcription of E-cadherin. Inhibition of Snail function in epithelial cancer
      cell lines lacking E-cadherin protein restores the expression of the E-cadherin
      gene.
FAU - Batlle, E
AU  - Batlle E
AD  - Unitat de Biologia Cel.lular i Molecular, Institut Municipal d'Investigacio
      Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain.
FAU - Sancho, E
AU  - Sancho E
FAU - Franci, C
AU  - Franci C
FAU - Dominguez, D
AU  - Dominguez D
FAU - Monfar, M
AU  - Monfar M
FAU - Baulida, J
AU  - Baulida J
FAU - Garcia De Herreros, A
AU  - Garcia De Herreros A
LA  - eng
SI  - GENBANK/AF131208
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Cadherins)
RN  - 0 (DNA, Antisense)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Binding Sites
MH  - Cadherins/biosynthesis/*genetics
MH  - DNA, Antisense
MH  - DNA-Binding Proteins/*metabolism
MH  - Down-Regulation
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Neoplasms, Glandular and Epithelial/*genetics
MH  - Promoter Regions, Genetic
MH  - Protein Binding
MH  - RNA, Messenger/biosynthesis
MH  - Repressor Proteins/*metabolism
MH  - Snail Family Transcription Factors
MH  - Transcription Factors/*metabolism
EDAT- 2000/02/03 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/02/03 09:00
PHST- 2000/02/03 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/02/03 09:00 [entrez]
AID - 10.1038/35000034 [doi]
PST - ppublish
SO  - Nat Cell Biol. 2000 Feb;2(2):84-9. doi: 10.1038/35000034.