PMID- 10655551
OWN - NLM
STAT- MEDLINE
DCOM- 20000504
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 9
IP  - 3
DP  - 2000 Feb 12
TI  - Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental 
      defects of structures affected in the Miller-Dieker syndrome.
PG  - 413-9
AB  - HIC1 is a candidate tumor suppressor gene which is frequently hypermethylated in 
      human tumors, and its location within the Miller-Dieker syndrome's critical
      deletion region at chromosome 17p13.3 makes it a candidate gene for involvement
      in this gene deletion syndrome. To study the function of murine Hic1 in
      development, we have created Hic1 -deficient mice. These animals die perinatally 
      and exhibit varying combinations of gross developmental defects throughout the
      second half of development, including acrania, exencephaly, cleft palate, limb
      abnormalities and omphalocele. These findings demonstrate a role for Hic1 in the 
      development of structures affected in the Miller-Dieker syndrome, and provide
      functional evidence to strengthen its candidacy as a gene involved in this
      disorder.
FAU - Carter, M G
AU  - Carter MG
AD  - Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins
      University School of Medicine, Baltimore, MD 21205, USA.
FAU - Johns, M A
AU  - Johns MA
FAU - Zeng, X
AU  - Zeng X
FAU - Zhou, L
AU  - Zhou L
FAU - Zink, M C
AU  - Zink MC
FAU - Mankowski, J L
AU  - Mankowski JL
FAU - Donovan, D M
AU  - Donovan DM
FAU - Baylin, S B
AU  - Baylin SB
LA  - eng
GR  - CA43318/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Hic1 protein, mouse)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Abnormalities, Multiple/genetics/pathology
MH  - Animals
MH  - Blotting, Southern
MH  - Embryo, Mammalian/abnormalities
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Syndrome
MH  - Transcription Factors/*genetics/metabolism
EDAT- 2000/02/03 09:00
MHDA- 2000/05/08 09:00
CRDT- 2000/02/03 09:00
PHST- 2000/02/03 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 2000/02/03 09:00 [entrez]
AID - ddd047 [pii]
AID - 10.1093/hmg/9.3.413 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2000 Feb 12;9(3):413-9. doi: 10.1093/hmg/9.3.413.