PMID- 10655480
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20191210
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 97
IP  - 3
DP  - 2000 Feb 1
TI  - A family of chromatin remodeling factors related to Williams syndrome
      transcription factor.
PG  - 1038-43
AB  - Chromatin remodeling complexes have been implicated in the disruption or
      reformation of nucleosomal arrays resulting in modulation of transcription, DNA
      replication, and DNA repair. Here we report the isolation of WCRF, a new
      chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits,
      WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to 
      the Williams syndrome transcription factor. WCRF180 is a member of a family of
      proteins sharing a putative heterochromatin localization domain, a PHD finger,
      and a bromodomain, prevalent in factors involved in regulation of chromatin
      structure.
FAU - Bochar, D A
AU  - Bochar DA
AD  - The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
FAU - Savard, J
AU  - Savard J
FAU - Wang, W
AU  - Wang W
FAU - Lafleur, D W
AU  - Lafleur DW
FAU - Moore, P
AU  - Moore P
FAU - Cote, J
AU  - Cote J
FAU - Shiekhattar, R
AU  - Shiekhattar R
LA  - eng
SI  - GENBANK/AF221130
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Acf protein, Drosophila)
RN  - 0 (BAZ1A protein, human)
RN  - 0 (Chromatin)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Fungal Proteins)
RN  - 0 (ISWI protein)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nucleosomes)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Ribonucleoprotein, U1 Small Nuclear)
RN  - 0 (SMARCA1 protein, human)
RN  - 0 (SMARCA2 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (snf protein, Drosophila)
RN  - EC 3.1.21.1 (Deoxyribonuclease I)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.1.- (SMARCA4 protein, human)
RN  - EC 3.6.4.- (DNA Helicases)
SB  - IM
MH  - Adenosine Triphosphatases/genetics/*isolation & purification/physiology
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromatin/*metabolism/ultrastructure
MH  - Chromosomal Proteins, Non-Histone
MH  - DNA Helicases
MH  - DNA-Binding Proteins/metabolism
MH  - Deoxyribonuclease I/metabolism
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/genetics
MH  - Fungal Proteins/physiology
MH  - HeLa Cells
MH  - Humans
MH  - Macromolecular Substances
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/genetics/isolation & purification/physiology
MH  - *Nuclear Proteins
MH  - Nucleosomes/metabolism
MH  - Protein Structure, Tertiary
MH  - *RNA-Binding Proteins
MH  - Ribonucleoprotein, U1 Small Nuclear/physiology
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Transcription Factors/chemistry/genetics/*isolation &
      purification/metabolism/physiology
MH  - Williams Syndrome/*genetics
PMC - PMC15513
EDAT- 2000/02/03 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/03 09:00
PHST- 2000/02/03 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/03 09:00 [entrez]
AID - 10.1073/pnas.97.3.1038 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1038-43. doi: 10.1073/pnas.97.3.1038.