PMID- 10653479
OWN - NLM
STAT- MEDLINE
DCOM- 20000306
LR  - 20190921
IS  - 0145-479X (Print)
IS  - 0145-479X (Linking)
VI  - 31
IP  - 5
DP  - 1999 Oct
TI  - Mitochondrial proton leak and the uncoupling proteins.
PG  - 517-25
AB  - An energetically significant leak of protons occurs across the mitochondrial
      inner membranes of eukaryotic cells. This seemingly wasteful proton leak accounts
      for at least 20% of the standard metabolic rate of a rat. There is evidence that 
      it makes a similar contribution to standard metabolic rate in a lizard. Proton
      conductance of the mitochondrial inner membrane can be considered as having two
      components: a basal component present in all mitochondria, and an augmentative
      component, which may occur in tissues of mammals and perhaps of some other
      animals. The uncoupling protein of brown adipose tissue, UCP1, is a clear example
      of such an augmentative component. The newly discovered UCP1 homologs, UCP2,
      UCP3, and brain mitochondrial carrier protein 1 (BMCP1) may participate in the
      augmentative component of proton leak. However, they do not appear to catalyze
      the basal leak, as this is observed in mitochondria from cells which apparently
      lack these proteins. Whereas UCP1 plays an important role in thermogenesis, the
      evidence that UCP2 and UCP3 do likewise remains equivocal.
FAU - Stuart, J A
AU  - Stuart JA
AD  - Department of Biochemistry, University of Cambridge, UK.
FAU - Brindle, K M
AU  - Brindle KM
FAU - Harper, J A
AU  - Harper JA
FAU - Brand, M D
AU  - Brand MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Bioenerg Biomembr
JT  - Journal of bioenergetics and biomembranes
JID - 7701859
RN  - 0 (Carrier Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Proteins)
RN  - 0 (Protons)
RN  - 0 (UCP1 protein, human)
RN  - 0 (UCP2 protein, human)
RN  - 0 (UCP3 protein, human)
RN  - 0 (Ucp1 protein, rat)
RN  - 0 (Ucp2 protein, rat)
RN  - 0 (Ucp3 protein, rat)
RN  - 0 (Uncoupling Agents)
RN  - 0 (Uncoupling Protein 1)
RN  - 0 (Uncoupling Protein 2)
RN  - 0 (Uncoupling Protein 3)
SB  - IM
MH  - Adipose Tissue, Brown/*metabolism
MH  - Animals
MH  - Carrier Proteins/genetics/*metabolism
MH  - Humans
MH  - Invertebrates/metabolism
MH  - Ion Channels
MH  - Membrane Proteins/genetics/*metabolism
MH  - *Membrane Transport Proteins
MH  - Mitochondria/*metabolism
MH  - *Mitochondrial Proteins
MH  - Proteins/genetics/metabolism
MH  - *Protons
MH  - Rats
MH  - Uncoupling Agents/*metabolism
MH  - Uncoupling Protein 1
MH  - Uncoupling Protein 2
MH  - Uncoupling Protein 3
RF  - 36
EDAT- 2000/02/01 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
AID - 10.1023/a:1005456725549 [doi]
PST - ppublish
SO  - J Bioenerg Biomembr. 1999 Oct;31(5):517-25. doi: 10.1023/a:1005456725549.