PMID- 10652563
OWN - NLM
STAT- MEDLINE
DCOM- 20000215
LR  - 20041117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 4B
DP  - 1999 Jul-Aug
TI  - Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4.
PG  - 2843-52
AB  - The human kallikrein gene family is localized on chromosome 19q13.3-q13.4 and
      currently includes three members: KLK1 or pancreatic/renal kallikrein, KLK2 or
      human glandular kallikrein and KLK3 or prostate-specific antigen (PSA). The
      latter two genes are almost prostate-specific and they are used for diagnosis and
      monitoring of prostate cancer and more recently, in breast cancer applications.
      In this paper, we analyzed a 300Kb genomic DNA region around chromosome
      19q13.3-q13.4 in an effort to map known kallikrein or kallikrein-like genes and
      identify new kallikrein-like genes. Using the known kallikrein or kallikrein-like
      genes PSA, KLK2, enzyme and normal epithelial cell-specific 1 gene (NES1) as
      landmarks, we have identified another six novel genes of which, five have protein
      homologies and gene structure similarities with other kallikreins or
      kallikrein-like genes. We conclude, contrary to the current belief, that the
      human kallikrein gene locus contains a large number of kallikrein-like genes (at 
      least thirteen). In this paper, we present a detailed description of the human
      kallikrein gene locus, encompassing the already known and newly identified genes.
      These new genes, like the already known kallikreins, may have utility for
      diagnosis, monitoring and therapeutics of various cancers including those of the 
      breast, prostate and testis.
FAU - Yousef, G M
AU  - Yousef GM
AD  - Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
FAU - Luo, L Y
AU  - Luo LY
FAU - Diamandis, E P
AU  - Diamandis EP
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 3.4.21.- (Kallikreins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - Humans
MH  - Kallikreins/*genetics
MH  - Molecular Sequence Data
MH  - Sequence Homology, Amino Acid
EDAT- 2000/02/01 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 Jul-Aug;19(4B):2843-52.