PMID- 10652539
OWN - NLM
STAT- MEDLINE
DCOM- 20000217
LR  - 20190915
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 23
IP  - 2
DP  - 2000 Feb
TI  - Is CREB a key to neuronal survival?
PG  - 48-53
AB  - A range of molecules control nerve-cell survival in the brain. Many of these
      molecules might be neuroprotective through activation of the transcription factor
      cAMP-response-element-binding protein (CREB). Activation of CREB, by
      phosphorylation of Ser133, occurs in brain-damage-resistant hippocampal dentate
      granule cells and is triggered by neuroprotective environmental stimulation. In
      addition, the Akt neuroprotective signaling pathway activates CREB, and CREB
      synthesis and phosphorylation promote the survival of many cells, including
      neurons, in vitro. Thus, CREB might be responsible for programmed nerve-cell
      survival. Studies investigating its role in the brain are now required to confirm
      these in vitro results, and the downstream survival genes, whose expression is
      activated by CREB in neurons, need to be identified.
FAU - Walton, M R
AU  - Walton MR
AD  - Dept of Pharmacology, Faculty of Medical and Health Sciences, University of
      Auckland, Auckland, New Zealand.
FAU - Dragunow, I
AU  - Dragunow I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Growth Substances)
SB  - IM
MH  - Animals
MH  - Cell Survival
MH  - Cyclic AMP Response Element-Binding Protein/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Growth Substances/physiology
MH  - Hippocampus/cytology/metabolism
MH  - Humans
MH  - Neurons/*cytology/*metabolism
MH  - Phosphorylation
RF  - 61
EDAT- 2000/02/01 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
AID - S0166-2236(99)01500-3 [pii]
AID - 10.1016/s0166-2236(99)01500-3 [doi]
PST - ppublish
SO  - Trends Neurosci. 2000 Feb;23(2):48-53. doi: 10.1016/s0166-2236(99)01500-3.