PMID- 10652516
OWN - NLM
STAT- MEDLINE
DCOM- 20000223
LR  - 20191024
IS  - 0962-8924 (Print)
IS  - 0962-8924 (Linking)
VI  - 10
IP  - 2
DP  - 2000 Feb
TI  - Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors.
PG  - 60-7
AB  - ARF proteins are important regulators of membrane dynamics and protein transport 
      within the eukaryotic cell. The Sec7 domain is approximately 200 amino acids in
      size and stimulates guanine-nucleotide exchange on members of the ARF class of
      small GTPases. The members of one subclass of Sec7-domain proteins are direct
      targets of the secretion-inhibiting drug brefeldin A, which blocks the exchange
      reaction by trapping a reaction intermediate in an inactive, abortive complex. A 
      separate subclass of Sec7-domain proteins is involved in signal transduction and 
      possess a domain that mediates membrane binding in response to extracellular
      signals.
FAU - Jackson, C L
AU  - Jackson CL
AD  - Service de Biochimie et Genetique Moleculaire, CEA/Saclay, Gif-sur-Yvette,
      France. cathy@jonas.saclay.cea.fr
FAU - Casanova, J E
AU  - Casanova JE
LA  - eng
GR  - AI32991/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Fungal Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Sec7 guanine nucleotide exchange factors)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factor 1)
SB  - IM
MH  - ADP-Ribosylation Factor 1/*metabolism
MH  - Animals
MH  - Fungal Proteins/chemistry/pharmacology/physiology
MH  - Guanine Nucleotide Exchange Factors/chemistry/pharmacology/physiology
MH  - Humans
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
MH  - Saccharomyces cerevisiae
MH  - Sequence Homology, Amino Acid
RF  - 58
EDAT- 2000/02/01 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
AID - S0962-8924(99)01699-2 [pii]
AID - 10.1016/s0962-8924(99)01699-2 [doi]
PST - ppublish
SO  - Trends Cell Biol. 2000 Feb;10(2):60-7. doi: 10.1016/s0962-8924(99)01699-2.