PMID- 10652278
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20181113
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 14
IP  - 2
DP  - 2000 Jan 15
TI  - A forkhead gene, FoxE3, is essential for lens epithelial proliferation and
      closure of the lens vesicle.
PG  - 245-54
AB  - In the mouse mutant dysgenetic lens (dyl) the lens vesicle fails to separate from
      the ectoderm, causing a fusion between the lens and the cornea. Lack of a
      proliferating anterior lens epithelium leads to absence of secondary lens fibers 
      and a dysplastic, cataractic lens. We report the cloning of a gene, FoxE3,
      encoding a forkhead/winged helix transcription factor, which is expressed in the 
      developing lens from the start of lens placode induction and becomes restricted
      to the anterior proliferating cells when lens fiber differentiation begins. We
      show that FoxE3 is colocalized with dyl in the mouse genome, that dyl mice have
      mutations in the part of FoxE3 encoding the DNA-binding domain, and that these
      mutations cosegregate with the dyl phenotype. During embryonic development, the
      primordial lens epithelium is formed in an apparently normal way in dyl mutants. 
      However, instead of the proliferation characteristic of a normal lens epithelium,
      the posterior of these cells fail to divide and show signs of premature
      differentiation, whereas the most anterior cells are eliminated by apoptosis.
      This implies that FoxE3 is essential for closure of the lens vesicle and is a
      factor that promotes survival and proliferation, while preventing
      differentiation, in the lens epithelium.
FAU - Blixt, A
AU  - Blixt A
AD  - Department of Molecular Biology, Goteborg University, The Lundberg Laboratory,
      Medicinaregatan 9C, Box 462, S-405 30 Goteborg, Sweden.
FAU - Mahlapuu, M
AU  - Mahlapuu M
FAU - Aitola, M
AU  - Aitola M
FAU - Pelto-Huikko, M
AU  - Pelto-Huikko M
FAU - Enerback, S
AU  - Enerback S
FAU - Carlsson, P
AU  - Carlsson P
LA  - eng
SI  - GENBANK/AF142647
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (FOXE3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxe3 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis/genetics/physiology
MH  - Cell Differentiation/genetics/physiology
MH  - Cell Division/genetics
MH  - Chromosome Segregation/genetics/physiology
MH  - Cloning, Molecular
MH  - Epithelial Cells/*cytology/pathology/physiology
MH  - Forkhead Transcription Factors
MH  - Humans
MH  - Lens, Crystalline/cytology/embryology/metabolism/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Mutant Strains
MH  - Molecular Sequence Data
MH  - Mutation/genetics/physiology
MH  - Phenotype
MH  - Transcription Factors/biosynthesis/*genetics/metabolism/physiology
PMC - PMC316354
EDAT- 2000/02/01 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
PST - ppublish
SO  - Genes Dev. 2000 Jan 15;14(2):245-54.