PMID- 10652269
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20181113
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 14
IP  - 2
DP  - 2000 Jan 15
TI  - An essential role in liver development for transcription factor XBP-1.
PG  - 152-7
AB  - XBP-1 is a CREB/ATF family transcription factor highly expressed in
      hepatocellular carcinomas. Here we report that XBP-1 is essential for liver
      growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced
      hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient
      hematopoietic progenitors had no cell-autonomous defect in differentiation.
      Rather, hepatocyte development itself was severely impaired by two measures:
      diminished growth rate and prominent apoptosis. Specific target genes of XBP-1 in
      the liver were identified as alphaFP, which may be a regulator of hepatocyte
      growth, and three acute phase protein family members. Therefore, XBP-1 is a
      transcription factor essential for hepatocyte growth.
FAU - Reimold, A M
AU  - Reimold AM
AD  - Department of Immunology and Infectious Diseases, Harvard School of Public
      Health, Boston, Massachusetts 02115 USA.
FAU - Etkin, A
AU  - Etkin A
FAU - Clauss, I
AU  - Clauss I
FAU - Perkins, A
AU  - Perkins A
FAU - Friend, D S
AU  - Friend DS
FAU - Zhang, J
AU  - Zhang J
FAU - Horton, H F
AU  - Horton HF
FAU - Scott, A
AU  - Scott A
FAU - Orkin, S H
AU  - Orkin SH
FAU - Byrne, M C
AU  - Byrne MC
FAU - Grusby, M J
AU  - Grusby MJ
FAU - Glimcher, L H
AU  - Glimcher LH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (Xbp1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - DNA-Binding Proteins/biosynthesis/deficiency/genetics/*physiology
MH  - Embryonic and Fetal Development/genetics
MH  - Gene Targeting
MH  - Genes, Lethal/genetics
MH  - Hepatectomy
MH  - Liver/abnormalities/*embryology/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Regulatory Factor X Transcription Factors
MH  - Stem Cells
MH  - Transcription Factors/biosynthesis/deficiency/genetics/*physiology
MH  - X-Box Binding Protein 1
PMC - PMC316338
EDAT- 2000/02/01 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
PST - ppublish
SO  - Genes Dev. 2000 Jan 15;14(2):152-7.