PMID- 10652252
OWN - NLM
STAT- MEDLINE
DCOM- 20000412
LR  - 20061115
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 113 ( Pt 4)
DP  - 2000 Feb
TI  - ERGIC-53 and traffic in the secretory pathway.
PG  - 587-96
AB  - The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a
      mannose-specific membrane lectin operating as a cargo receptor for the transport 
      of glycoproteins from the ER to the ERGIC. Lack of functional ERGIC-53 leads to a
      selective defect in secretion of glycoproteins in cultured cells and to
      hemophilia in humans. Beyond its interest as a transport receptor, ERGIC-53 is an
      attractive probe for studying numerous aspects of protein trafficking in the
      secretory pathway, including traffic routes, mechanisms of anterograde and
      retrograde traffic, retention of proteins in the ER, and the function of the
      ERGIC. Understanding these fundamental processes of cell biology will be crucial 
      for the elucidation and treatment of many inherited and acquired diseases, such
      as cystic fibrosis, Alzheimer's disease and viral infections.
FAU - Hauri, H P
AU  - Hauri HP
AD  - Department of Pharmacology, Biozentrum, University of Basel, CH-4056 Basel,
      Switzerland. Hans-Peter.Hauri@unibas.ch
FAU - Kappeler, F
AU  - Kappeler F
FAU - Andersson, H
AU  - Andersson H
FAU - Appenzeller, C
AU  - Appenzeller C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Animals
MH  - Biological Transport/physiology
MH  - Cell Compartmentation/physiology
MH  - Cytoplasmic Granules/*metabolism
MH  - Endoplasmic Reticulum/*metabolism
MH  - Eukaryotic Cells/*metabolism
MH  - Golgi Apparatus/*metabolism
MH  - *Mannose-Binding Lectins
MH  - Membrane Proteins/*metabolism
RF  - 121
EDAT- 2000/02/01 09:00
MHDA- 2000/04/15 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/04/15 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
PST - ppublish
SO  - J Cell Sci. 2000 Feb;113 ( Pt 4):587-96.