PMID- 10651484
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20041117
IS  - 1059-7794 (Print)
IS  - 1059-7794 (Linking)
VI  - 12
IP  - 3
DP  - 1998
TI  - Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and
      carcinoma of the pancreas. Mutations in brief no. 170. Online.
PG  - 212
AB  - Germ-line mutations in the p16/CDKN2 gene are known to predispose to melanoma.
      This gene belongs to a family of cyclin-dependent kinase inhibitors and blocks
      G1-S progression. The occurrence of p16/CDKN2 germline mutations in 12 Icelandic 
      melanoma kindreds (kindreds with two or more cases of melanoma or melanoma,
      pancreas and/or glioma cases) was examined. No germ-line mutation was found,
      however five mutations not previously discribed in solid tumours were identified,
      Pro48Leu, Ala57Val, Gly89Asp, Leu117Met, Tyr129Stop.
FAU - Gretarsdottir, S
AU  - Gretarsdottir S
AD  - Molecular and Cell Biology Reseach Laboratory, Reykjavik, Iceland.
      solveig@krabb.is
FAU - Olafsdottir, G H
AU  - Olafsdottir GH
FAU - Borg, A
AU  - Borg A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
SB  - IM
MH  - Carcinoma/*genetics
MH  - Genes, p16/*genetics
MH  - Germ-Line Mutation/*genetics
MH  - Glioma/*genetics
MH  - Humans
MH  - Melanoma/*genetics
MH  - Pancreatic Neoplasms/*genetics
EDAT- 2000/01/29 00:00
MHDA- 2000/01/29 00:01
CRDT- 2000/01/29 00:00
PHST- 2000/01/29 00:00 [pubmed]
PHST- 2000/01/29 00:01 [medline]
PHST- 2000/01/29 00:00 [entrez]
PST - ppublish
SO  - Hum Mutat. 1998;12(3):212.