PMID- 10649565
OWN - NLM
STAT- MEDLINE
DCOM- 20000407
LR  - 20190508
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 3
IP  - 2
DP  - 2000 Feb
TI  - A metabotropic glutamate receptor variant functions as a taste receptor.
PG  - 113-9
AB  - Sensory transduction for many taste stimuli such as sugars, some bitter compounds
      and amino acids is thought to be mediated via G protein-coupled receptors
      (GPCRs), although no such receptors that respond to taste stimuli are yet
      identified. Monosodium L-glutamate (L-MSG), a natural component of many foods, is
      an important gustatory stimulus believed to signal dietary protein. We describe a
      GPCR cloned from rat taste buds and functionally expressed in CHO cells. The
      receptor couples negatively to a cAMP cascade and shows an unusual
      concentration-response relationship. The similarity of its properties to MSG
      taste suggests that this receptor is a taste receptor for glutamate.
FAU - Chaudhari, N
AU  - Chaudhari N
AD  - Program in Neuroscience, University of Miami School of Medicine, P.O. Box 016430 
      (R430), Miami, Florida 33101, USA. nchaudhari@miami.edu
FAU - Landin, A M
AU  - Landin AM
FAU - Roper, S D
AU  - Roper SD
LA  - eng
GR  - DC 03013/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (2-amino-4-phosphono-propinate)
RN  - 0 (DNA, Complementary)
RN  - 0 (Propionates)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 1F7A44V6OU (Colforsin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - YZN9W7P1BX (metabotropic glutamate receptor 4)
SB  - IM
CIN - Nat Neurosci. 2000 Feb;3(2):99-100. PMID: 10649560
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/metabolism
MH  - CHO Cells
MH  - Chemoreceptor Cells/*metabolism
MH  - Cloning, Molecular
MH  - Colforsin/pharmacology
MH  - Cricetinae
MH  - Cyclic AMP/metabolism
MH  - DNA, Complementary/genetics
MH  - Dose-Response Relationship, Drug
MH  - GTP-Binding Proteins/metabolism
MH  - Glutamic Acid/*metabolism/pharmacology
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Polymerase Chain Reaction
MH  - Propionates/pharmacology
MH  - Protein Isoforms/genetics/*metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Receptors, Metabotropic Glutamate/genetics/*metabolism
MH  - Taste/*physiology
MH  - Taste Buds/*metabolism
MH  - Transfection
EDAT- 2000/01/29 09:00
MHDA- 2001/03/23 10:01
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - 10.1038/72053 [doi]
PST - ppublish
SO  - Nat Neurosci. 2000 Feb;3(2):113-9. doi: 10.1038/72053.