PMID- 10648897
OWN - NLM
STAT- MEDLINE
DCOM- 20000307
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 75
IP  - 1
DP  - 2000 Jan 10
TI  - 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain
      during development.
PG  - 138-42
AB  - This study reports the expression of the ubiquitous
      6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3)
      (PFK-2/FBPase-2) in different stages of rat brain development. Northern blot and 
      RT-PCR analysis demonstrated that ubiquitous PFK-2/FBPase-2 is expressed in rat
      brain from embryonic to adult life and shows a transient increase 1 day before
      birth, coincident with the maximum concentration of Fru-2,6-P(2) and PFK-2
      activity. The levels of brain PFK-2/FBPase-2 gene expression as well as the
      enzymatic activity and the concentration of Fru-2,6-P(2) appear to be remarkably 
      constant during adult life, without significant differences in the brain
      hippocampus, cortex, cerebellum or striatum areas.
FAU - Goren, N
AU  - Goren N
AD  - Catedra de Farmacologia, Facultad de Odontologia, Universidad de Buenos Aires,
      CEFYBO-CONICET, Buenos Aires, Argentina.
FAU - Manzano, A
AU  - Manzano A
FAU - Riera, L
AU  - Riera L
FAU - Ambrosio, S
AU  - Ambrosio S
FAU - Ventura, F
AU  - Ventura F
FAU - Bartrons, R
AU  - Bartrons R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Multienzyme Complexes)
RN  - EC 2.7.1.105 (Phosphofructokinase-2)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 3.1.3.11 (Fructose-Bisphosphatase)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/embryology/*enzymology/growth & development
MH  - Embryonic and Fetal Development/*physiology
MH  - Female
MH  - Fructose-Bisphosphatase/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Enzymologic
MH  - Gestational Age
MH  - Male
MH  - Multienzyme Complexes/*genetics
MH  - Phosphofructokinase-1/*genetics
MH  - Phosphofructokinase-2
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2000/01/29 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0169328X99003198 [pii]
AID - 10.1016/s0169-328x(99)00319-8 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2000 Jan 10;75(1):138-42. doi:
      10.1016/s0169-328x(99)00319-8.