PMID- 10648820
OWN - NLM
STAT- MEDLINE
DCOM- 20000222
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 466
IP  - 1
DP  - 2000 Jan 21
TI  - Association of Cbl with Fms and p85 in response to macrophage colony-stimulating 
      factor.
PG  - 96-100
AB  - Tyrosine phosphorylation of Cbl and its association with signal-transducing 
      molecules in response to macrophage colony-stimulating factor (M-CSF) were 
      analyzed by using cell lines which express the wild-type and a mutant M-CSF 
      receptor, Fms. We found that in a clone, F723 TF-1 cells expressing mutant Fms in 
      which tyrosine 723 had been substituted with phenylalanine, the M-CSF 
      stimulation-dependent association between Cbl and Fms was markedly impaired. 
      However, phosphorylation of Cbl and its association with the p85 subunit of 
      phosphatidylinositol 3-kinase were induced in these mutant cells as seen in the 
      wild-type fms transfectant. These results suggest that phosphorylation of 
      tyrosine 723 is particularly important for the recruitment of Cbl to the M-CSF 
      receptor, but is not required for the phosphorylation and binding of Cbl to 
      signal-transducing molecules such as p85.
FAU - Ota, J
AU  - Ota J
AD  - Biochemical Research Laboratory, Morinaga Milk Industry, Higashihara 5-1-83, 
      Zama, Kanagawa, Japan.
FAU - Sato, K
AU  - Sato K
FAU - Kimura, F
AU  - Kimura F
FAU - Wakimoto, N
AU  - Wakimoto N
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Nagata, N
AU  - Nagata N
FAU - Suzu, S
AU  - Suzu S
FAU - Yamada, M
AU  - Yamada M
FAU - Shimamura, S
AU  - Shimamura S
FAU - Motoyoshi, K
AU  - Motoyoshi K
LA  - eng
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA Primers)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 42HK56048U (Tyrosine)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-cbl)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, Macrophage Colony-Stimulating Factor)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.88 (peptide deformylase)
RN  - EC 6.3.2.- (CBL protein, human)
RN  - EC 6.3.2.- (Cbl protein, mouse)
SB  - IM
MH  - *Amidohydrolases
MH  - Amino Acid Substitution
MH  - Aminopeptidases/chemistry/genetics/*metabolism
MH  - Animals
MH  - Base Sequence
MH  - Clone Cells
MH  - DNA Primers/genetics
MH  - Humans
MH  - Macrophage Colony-Stimulating Factor/metabolism/*pharmacology
MH  - Mice
MH  - Mutagenesis, Site-Directed
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-cbl
MH  - Receptor, Macrophage Colony-Stimulating Factor/metabolism
MH  - Recombinant Proteins/chemistry/genetics/metabolism
MH  - Signal Transduction
MH  - Substrate Specificity
MH  - Transfection
MH  - Tyrosine/chemistry
MH  - *Ubiquitin-Protein Ligases
EDAT- 2000/01/29 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0014-5793(99)01767-6 [pii]
AID - 10.1016/s0014-5793(99)01767-6 [doi]
PST - ppublish
SO  - FEBS Lett. 2000 Jan 21;466(1):96-100. doi: 10.1016/s0014-5793(99)01767-6.