PMID- 10648817
OWN - NLM
STAT- MEDLINE
DCOM- 20000222
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 466
IP  - 1
DP  - 2000 Jan 21
TI  - Different transcriptional properties of mSim-1 and mSim-2.
PG  - 80-6
AB  - The mSim-1 and mSim-2 gene products are mammalian homologues of the Drosophila
      Sim gene. The dSim gene product transactivates through a DNA binding site known
      as the CNS midline enhancer (CME) element. We have investigated the
      transcriptional properties of mSIM-1 and mSIM-2 mediated through the CME element 
      in concert with their dimerization partners, ARNT and ARNT-2. The mSIM-1/ARNT
      heterodimer transactivates reporter constructs via the ARNT carboxy-terminus.
      However, mSIM-2 quenches ARNT transactivation. We find that mSIM-2 competes with 
      mSIM-1 for binding to ARNT, suggesting a possible antagonism between these
      transcription factors.
FAU - Moffett, P
AU  - Moffett P
AD  - Department of Biochemistry, McGill University, 3655 Drummond St., Montreal, Que.,
      Canada.
FAU - Pelletier, J
AU  - Pelletier J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (ARNT protein, human)
RN  - 0 (ARNT2 protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SIM1 protein, human)
RN  - 0 (SIM2 protein, human)
RN  - 0 (Sim2 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Aryl Hydrocarbon Receptor Nuclear Translocator
MH  - Base Sequence
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Binding Sites/genetics
MH  - Binding, Competitive
MH  - Cell Line
MH  - DNA/genetics/metabolism
MH  - DNA Primers/genetics
MH  - *DNA-Binding Proteins
MH  - Helix-Loop-Helix Motifs/genetics
MH  - Humans
MH  - *Receptors, Aryl Hydrocarbon
MH  - Recombinant Proteins/genetics/metabolism
MH  - Repressor Proteins/*genetics/*metabolism
MH  - Transcription Factors/*genetics/*metabolism
MH  - Transcription, Genetic
MH  - Transcriptional Activation
EDAT- 2000/01/29 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0014-5793(99)01750-0 [pii]
AID - 10.1016/s0014-5793(99)01750-0 [doi]
PST - ppublish
SO  - FEBS Lett. 2000 Jan 21;466(1):80-6. doi: 10.1016/s0014-5793(99)01750-0.