PMID- 10648803
OWN - NLM
STAT- MEDLINE
DCOM- 20000222
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 466
IP  - 1
DP  - 2000 Jan 21
TI  - The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding 
      proteins localised to the secretory pathway of mammalian cells.
PG  - 11-8
AB  - The CREC family consists of a number of recently discovered multiple (up to
      seven) EF-hand proteins that localise to the secretory pathway of mammalian
      cells. At present, the family includes reticulocalbin, ERC-55/TCBP-49/E6BP,
      Cab45, calumenin and crocalbin/CBP-50. Similar proteins are found in quite
      diverse invertebrate organisms such as DCB-45 and SCF in Drosophila melanogaster,
      SCF in Bombyx mori, CCB-39 in Caenorhabditis elegans and Pfs40/PfERC in
      Plasmodium falciparum. The Ca(2+) affinity is rather low with dissociation
      constants around 10(-4)-10(-3) M. The proteins may participate in
      Ca(2+)-regulated activities. Recent evidence has been obtained that some CREC
      family members are involved in pathological activities such as malignant cell
      transformation, mediation of the toxic effects of snake venom toxins and putative
      participation in amyloid formation.
FAU - Honore, B
AU  - Honore B
AD  - Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle,
      Building 170, DK-8000, Aarhus, Denmark. bh@biokemi.au.dk
FAU - Vorum, H
AU  - Vorum H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Amyloid)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Snake Venoms)
RN  - SY7Q814VUP (Calcium)
SB  - IM
SB  - S
MH  - Amino Acid Sequence
MH  - Amyloid/biosynthesis
MH  - Animals
MH  - Calcium/metabolism
MH  - Calcium-Binding Proteins/chemistry/genetics/*metabolism
MH  - Cell Transformation, Neoplastic
MH  - Evolution, Molecular
MH  - Humans
MH  - Invertebrates
MH  - Kinetics
MH  - Mammals
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Protein Conformation
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Snake Venoms/toxicity
RF  - 42
EDAT- 2000/01/29 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0014-5793(99)01780-9 [pii]
AID - 10.1016/s0014-5793(99)01780-9 [doi]
PST - ppublish
SO  - FEBS Lett. 2000 Jan 21;466(1):11-8. doi: 10.1016/s0014-5793(99)01780-9.