PMID- 10648003
OWN - NLM
STAT- MEDLINE
DCOM- 20000209
LR  - 20210103
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 67
IP  - 1
DP  - 2000 Jan
TI  - Regulation of scavenger receptor CD163 expression in human monocytes and
      macrophages by pro- and antiinflammatory stimuli.
PG  - 97-103
AB  - CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich
      family (SRCR) is exclusively expressed on cells of the monocyte lineage. In
      freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the
      highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein
      expression is up-regulated during macrophage colony-stimulating factor
      (M-CSF)-dependent phagocytic differentiation of human blood monocytes. In
      contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-4) for
      dendritic differentiation down-regulate this antigen. CD163 expression is also
      suppressed by proinflammatory mediators like lipopolysaccharide (LPS),
      interferon-gamma (IFN-gamma), and tumor necrosis factor alpha, whereas IL-6 and
      the antiinflammatory cytokine interleukin-10 (IL-10) strongly up-regulate CD163
      mRNA in monocytes and macrophages. The effects of the immunosuppressants
      dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to
      influence CD163 mRNA levels. Our results demonstrate that CD163 expression in
      monocytes/macrophages is regulated by proinflammatory and antiinflammatory
      mediators. This expression pattern implies a functional role of CD 163 in the
      antiinflammatory response of monocytes.
FAU - Buechler, C
AU  - Buechler C
AD  - Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat 
      Regensburg, Germany.
FAU - Ritter, M
AU  - Ritter M
FAU - Orso, E
AU  - Orso E
FAU - Langmann, T
AU  - Langmann T
FAU - Klucken, J
AU  - Klucken J
FAU - Schmitz, G
AU  - Schmitz G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (Interleukins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Scarb1 protein, mouse)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - *Antigens, CD
MH  - Antigens, Differentiation, Myelomonocytic/*metabolism
MH  - Cells, Cultured
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
MH  - Humans
MH  - Inflammation/*metabolism/pathology
MH  - Interferon-gamma/pharmacology
MH  - Interleukins/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophage Colony-Stimulating Factor/pharmacology
MH  - Macrophages/*metabolism/pathology
MH  - *Membrane Proteins
MH  - Monocytes/*metabolism/pathology
MH  - Phagocytosis
MH  - *Receptors, Cell Surface
MH  - Receptors, Immunologic/metabolism
MH  - *Receptors, Lipoprotein
MH  - Receptors, Scavenger
MH  - Scavenger Receptors, Class B
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2000/01/27 00:00
MHDA- 2000/01/27 00:01
CRDT- 2000/01/27 00:00
PHST- 2000/01/27 00:00 [pubmed]
PHST- 2000/01/27 00:01 [medline]
PHST- 2000/01/27 00:00 [entrez]
PST - ppublish
SO  - J Leukoc Biol. 2000 Jan;67(1):97-103.