PMID- 10647888
OWN - NLM
STAT- MEDLINE
DCOM- 20000216
LR  - 20220321
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 105
IP  - 6
DP  - 1999 Dec
TI  - A novel gene containing LIM domains (LIMD1) is located within the common
      eliminated region 1 (C3CER1) in 3p21.3.
PG  - 552-9
AB  - Chromosomal deletions on 3p have been described in a large number of human
      tumors, suggesting the presence of a tumor suppressor gene(s). Using an
      experimental system, called the elimination test, we previously identified a 1 Mb
      segment, the common eliminated region 1 (C3CER1). C3CER1 was also covered by a
      PAC contig. Using the sequence of two overlapping PACs from C3CER1, we localized 
      the human KIAA0028 cDNA, encoding the precursor of mitochondrial leucyl-tRNA
      synthetase. We also characterized a novel human LIM domain-containing gene
      (LIMD1) and its mouse ortholog (Limd1). LIM domains consist of a cysteine-rich
      consensus sequence containing two distinct zinc-binding subdomains, which mediate
      protein-protein interactions. The predicted protein sequences of the human and
      mouse genes reveal three LIM domains located at the C-terminal end, which
      indicates that they belong to the group 3 of the gene family encoding LIM motifs.
      We characterized the genomic structure of the human LIMD1 gene and assigned the
      mouse Limd1 gene to the chromosome 9F subtelomeric region. Both genes are
      ubiquitously expressed at the mRNA level. The LIM motif has been previously
      identified in many developmentally important factors from various eukaryotes.
      These factors have been shown to play a role in intracellular signaling,
      transcriptional regulation and cellular differentiation during development. The
      human C3CER1-located LIMD1 gene should therefore be further studied for its
      possible role in tumor suppression.
FAU - Kiss, H
AU  - Kiss H
AD  - Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
FAU - Kedra, D
AU  - Kedra D
FAU - Yang, Y
AU  - Yang Y
FAU - Kost-Alimova, M
AU  - Kost-Alimova M
FAU - Kiss, C
AU  - Kiss C
FAU - O'Brien, K P
AU  - O'Brien KP
FAU - Fransson, I
AU  - Fransson I
FAU - Klein, G
AU  - Klein G
FAU - Imreh, S
AU  - Imreh S
FAU - Dumanski, J P
AU  - Dumanski JP
LA  - eng
SI  - GENBANK/AJ132408
SI  - GENBANK/AJ132409
SI  - GENBANK/AJ132410
SI  - GENBANK/AJ132411
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (Carrier Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (LIMD1 protein, human)
RN  - 0 (Limd1 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Carrier Proteins/*genetics
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Genes, Tumor Suppressor/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intracellular Signaling Peptides and Proteins
MH  - LIM Domain Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Physical Chromosome Mapping
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/analysis
MH  - Sequence Alignment
MH  - Tumor Suppressor Proteins
EDAT- 2000/01/27 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/27 09:00
PHST- 2000/01/27 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/27 09:00 [entrez]
AID - 10.1007/s004399900188 [doi]
PST - ppublish
SO  - Hum Genet. 1999 Dec;105(6):552-9. doi: 10.1007/s004399900188.