PMID- 10647005
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20091119
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 402
IP  - 6758
DP  - 1999 Nov 11
TI  - A protein kinase encoded by the t complex responder gene causes non-mendelian
      inheritance.
PG  - 141-6
AB  - Males heterozygous for the t-haplotype form of mouse chromosome 17 preferentially
      transmit the t-chromosome to their progeny. Several distorter/sterility loci
      carried on the t-haplotype together impair flagellar function in all spermatozoa 
      whereas the responder, Tcr, rescues t-sperm but not wild-type sperm. Thus,
      t-sperm have an advantage over wild-type sperm in fertilizing egg cells. We have 
      isolated Tcr by positional cloning and show that it is a member of a novel
      protein kinase gene family, designated Smok, which is expressed late during
      spermiogenesis. Smok kinases are components of a signal cascade which may control
      sperm motility. Tcr has a reduced kinase activity, which may allow it to
      counterbalance a signalling impairment caused by the distorter/sterility loci.
      Tcr transgene constructs cause non-mendelian transmission of chromosomes on which
      they are carried, which leads to sex-ratio distortion when Tcr cosegregates with 
      the Y chromosome.
FAU - Herrmann, B G
AU  - Herrmann BG
AD  - Max-Planck-Institute of Immunobiology, Freiburg, Germany.
      herrmann@immunbio.mpg.de
FAU - Koschorz, B
AU  - Koschorz B
FAU - Wertz, K
AU  - Wertz K
FAU - McLaughlin, K J
AU  - McLaughlin KJ
FAU - Kispert, A
AU  - Kispert A
LA  - eng
SI  - GENBANK/AJ245452
SI  - GENBANK/AJ245453
SI  - GENBANK/AJ245454
SI  - GENBANK/AJ245455
SI  - GENBANK/AJ245456
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (Smok1 protein, mouse)
SB  - IM
CIN - Nature. 1999 Nov 11;402(6758):131-2. PMID: 10647000
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Gene Expression
MH  - Haplotypes
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Protein Kinases/*genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Sperm Motility
MH  - Sperm Tail
MH  - Spermatogenesis/genetics
MH  - Spermatozoa/*enzymology
EDAT- 2000/01/26 09:00
MHDA- 2001/03/23 10:01
CRDT- 2000/01/26 09:00
PHST- 2000/01/26 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 2000/01/26 09:00 [entrez]
AID - 10.1038/45970 [doi]
PST - ppublish
SO  - Nature. 1999 Nov 11;402(6758):141-6. doi: 10.1038/45970.