PMID- 10646843
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20220225
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 60
IP  - 1
DP  - 2000 Jan 1
TI  - Molecular cloning and characterization of human MAWD, a novel protein containing 
      WD-40 repeats frequently overexpressed in breast cancer.
PG  - 13-7
AB  - A full-length cDNA clone encoding a novel protein containing WD-40 repeats, which
      were frequently involved in protein-protein interactions, was isolated and
      sequenced. This clone had a predicted open reading frame (ORF) encoding 350 amino
      acids possessing six repeats of WD-40 motif. It was most closely homologous to
      TRIP-1, a phosphorylation substrate of the transforming growth factor-beta type
      II receptor. In the process of characterizing the function of the new gene
      product, we found that overexpression of the gene seemed to activate
      mitogen-activated protein kinase and to promote anchorage-independent growth of
      the cells. Moreover, the gene product was frequently overexpressed in human tumor
      breast tissues compared with their normal breast tissues, suggesting that the
      gene might be involved in the tumor progression. Radiation hybrid mapping placed 
      the gene into human chromosome 12q11-12 near the marker D12S1593.
FAU - Matsuda, S
AU  - Matsuda S
AD  - Department of Molecular Pathogenesis, Nagoya University School of Medicine,
      Japan. smatsuda@tsuru.med.nagoya-u.ac.jp
FAU - Katsumata, R
AU  - Katsumata R
FAU - Okuda, T
AU  - Okuda T
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Miyazaki, K
AU  - Miyazaki K
FAU - Senga, T
AU  - Senga T
FAU - Machida, K
AU  - Machida K
FAU - Thant, A A
AU  - Thant AA
FAU - Nakatsugawa, S
AU  - Nakatsugawa S
FAU - Hamaguchi, M
AU  - Hamaguchi M
LA  - eng
SI  - GENBANK/AB024327
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Eukaryotic Initiation Factor-3)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (STRAP protein, human)
RN  - 171601-26-6 (EIF3I protein, human)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Breast Neoplasms/*chemistry/metabolism
MH  - COS Cells
MH  - Carcinoma, Ductal, Breast/*chemistry/metabolism
MH  - Cloning, Molecular
MH  - Enzyme Activation
MH  - Eukaryotic Initiation Factor-3
MH  - Female
MH  - Humans
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*chemistry/metabolism
MH  - Open Reading Frames/genetics
MH  - Proteins/chemistry/metabolism
MH  - RNA-Binding Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Cells, Cultured
EDAT- 2000/01/26 00:00
MHDA- 2000/01/26 00:01
CRDT- 2000/01/26 00:00
PHST- 2000/01/26 00:00 [pubmed]
PHST- 2000/01/26 00:01 [medline]
PHST- 2000/01/26 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 2000 Jan 1;60(1):13-7.