PMID- 10646604
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20131121
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 403
IP  - 6766
DP  - 2000 Jan 13
TI  - A constitutively open potassium channel formed by KCNQ1 and KCNE3.
PG  - 196-9
AB  - Mutations in all four known KCNQ potassium channel alpha-subunit genes lead to
      human diseases. KCNQ1 (KvLQT1) interacts with the beta-subunit KCNE1 (IsK, minK) 
      to form the slow, depolarization-activated potassium current I(Ks) that is
      affected in some forms of cardiac arrhythmia. Here we show that the novel
      beta-subunit KCNE3 markedly changes KCNQ1 properties to yield currents that are
      nearly instantaneous and depend linearly on voltage. It also suppresses the
      currents of KCNQ4 and HERG potassium channels. In the intestine, KCNQ1 and KCNE3 
      messenger RNAs colocalized in crypt cells. This localization and the
      pharmacology, voltage-dependence and stimulation by cyclic AMP of KCNQ1/KCNE3
      currents indicate that these proteins may assemble to form the potassium channel 
      that is important for cyclic AMP-stimulated intestinal chloride secretion and
      that is involved in secretory diarrhoea and cystic fibrosis.
FAU - Schroeder, B C
AU  - Schroeder BC
AD  - Zentrum fur Molekulare Neurobiologie Hamburg, Hamburg University, Germany.
FAU - Waldegger, S
AU  - Waldegger S
FAU - Fehr, S
AU  - Fehr S
FAU - Bleich, M
AU  - Bleich M
FAU - Warth, R
AU  - Warth R
FAU - Greger, R
AU  - Greger R
FAU - Jentsch, T J
AU  - Jentsch TJ
LA  - eng
SI  - GENBANK/AF017002
SI  - GENBANK/AF076531
SI  - GENBANK/AF076533
SI  - GENBANK/M26685
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (KCNQ Potassium Channels)
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
RN  - 0 (Kcnq1 protein, mouse)
RN  - 0 (Kcnq1 protein, rat)
RN  - 0 (Potassium Channels)
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - 0 (potassium channel protein I(sk))
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Colon/metabolism
MH  - Cyclic AMP/metabolism
MH  - Electrochemistry
MH  - Humans
MH  - Intestine, Small/metabolism
MH  - KCNQ Potassium Channels
MH  - KCNQ1 Potassium Channel
MH  - Mice
MH  - Molecular Sequence Data
MH  - Potassium Channels/genetics/*metabolism
MH  - *Potassium Channels, Voltage-Gated
MH  - Rats
MH  - Xenopus
EDAT- 2000/01/26 09:00
MHDA- 2001/03/23 10:01
CRDT- 2000/01/26 09:00
PHST- 2000/01/26 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 2000/01/26 09:00 [entrez]
AID - 10.1038/35003200 [doi]
PST - ppublish
SO  - Nature. 2000 Jan 13;403(6766):196-9. doi: 10.1038/35003200.