PMID- 10645949
OWN - NLM
STAT- MEDLINE
DCOM- 20000324
LR  - 20181113
IS  - 1088-9051 (Print)
IS  - 1088-9051 (Linking)
VI  - 10
IP  - 1
DP  - 2000 Jan
TI  - Genetic localization of interacting modifiers affecting severity in a murine
      model of polycystic kidney disease.
PG  - 49-54
AB  - Genetic analysis of mouse disease models provides a means to investigate how
      modifying loci cause variation in phenotypic expression. We have shown that
      polycystic kidney disease (PKD) progression in the juvenile cystic kidney (jck)
      mutation can be influenced by an epistatic interaction between alleles of
      different strain backgrounds and we localized one of these loci to chromosome 1. 
      Using a chromosome 1 congenic strain, we improved the genetic analysis and mapped
      the interacting locus to proximal chromosome 4, with a highly significant lod
      association of 5.5. Re-analysis of the original F(2) cross reveals that in this
      cohort, while the lod association of the chromosome 4 locus alone is not
      significant, its effect is apparent when analyzed in combination with the
      chromosome 1 locus. This result suggests that correlation of paired genotype data
      with phenotype data will be an effective means to detect epistatic interactions
      contributing to complex traits, and that these associations can be tested using
      appropriate congenic lines.
FAU - Kuida, S
AU  - Kuida S
AD  - Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, 
      Massachusetts 02115 USA.
FAU - Beier, D R
AU  - Beier DR
LA  - eng
GR  - R01DK45639/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genome Res
JT  - Genome research
JID - 9518021
RN  - 0 (Genetic Markers)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (TRPP Cation Channels)
RN  - 0 (polycystic kidney disease 1 protein)
RN  - 0 (polycystic kidney disease 2 protein)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Chromosome Mapping
MH  - Crosses, Genetic
MH  - Disease Models, Animal
MH  - Genes, Recessive
MH  - Genetic Markers
MH  - Membrane Proteins/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Mutation/genetics
MH  - Polycystic Kidney Diseases/*genetics
MH  - Proteins/genetics
MH  - Severity of Illness Index
MH  - TRPP Cation Channels
PMC - PMC310498
EDAT- 2000/01/25 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
PST - ppublish
SO  - Genome Res. 2000 Jan;10(1):49-54.