PMID- 10644992
OWN - NLM
STAT- MEDLINE
DCOM- 20000207
LR  - 20061115
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 19
IP  - 1
DP  - 2000 Jan 6
TI  - The putative tumour suppressor Fus-2 is an N-acetyltransferase.
PG  - 161-3
AB  - Acetyltransferases are essential enzymes for a wide variety of cellular processes
      and mutations in acetyltransferase genes have been associated with the
      development of certain cancers. For this reason, we conducted a computerized
      sequence homology search for novel acetyltransferases. Here, we show that the
      putative tumour suppressor protein Fus-2 has homology to the catalytic domain of 
      acetyltransferases. We demonstrate that Fus-2 can acetylate the N-terminus of
      proteins using a ping-pong mechanism and that it has a specificity for
      substrates. Consistent with other N-acetyltransferases, Fus-2 localizes to the
      cytoplasm, as shown by GFP-tag experiments. Since the Fus-2 gene maps to the
      chromosomal region 3p21.3, which contains at least one tumour suppressor gene,
      the N-acetyltransferase functions of Fus-2 may be relevant to its potential role 
      in cancer.
FAU - Zegerman, P
AU  - Zegerman P
AD  - Wellcome/CRC Institute, Department of Pathology, Cambridge University, Tennis
      Court Road, Cambridge, CB2 1QR, UK.
FAU - Bannister, A J
AU  - Bannister AJ
FAU - Kouzarides, T
AU  - Kouzarides T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - EC 2.3.1.5 (Arylamine N-Acetyltransferase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Arylamine N-Acetyltransferase/genetics/*physiology
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Molecular Sequence Data
EDAT- 2000/01/25 00:00
MHDA- 2000/01/25 00:01
CRDT- 2000/01/25 00:00
PHST- 2000/01/25 00:00 [pubmed]
PHST- 2000/01/25 00:01 [medline]
PHST- 2000/01/25 00:00 [entrez]
AID - 10.1038/sj.onc.1203234 [doi]
PST - ppublish
SO  - Oncogene. 2000 Jan 6;19(1):161-3. doi: 10.1038/sj.onc.1203234.