PMID- 10644446
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20171116
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 3
DP  - 1999 Dec 15
TI  - Identification of a mammalian angiopoietin-related protein expressed specifically
      in liver.
PG  - 477-82
AB  - Based on searches of EST databases for signal sequences and amphipathic helices, 
      we have identified and cloned an angiopoietin-like gene, ANGPTL3. Multiple tissue
      Northern blots show that ANGPTL3 is expressed principally in the liver. ANGPTL3
      is expressed early during liver development, and expression is maintained in
      adult liver. Human ANGPTL3 is a 460-amino-acid polypeptide with the
      characteristic structure of angiopoietins: a signal peptide, an extended helical 
      domain predicted to form dimeric or trimeric coiled-coils, a short linker
      peptide, and a globular fibrinogen homology domain (FHD). Murine ANGPTL3 is a
      455-acid polypeptide encoded by seven exons on mouse chromosome 4, spanning about
      11 kb of DNA. ANGPTL3 contains the four conserved cysteines implicated in the
      intramolecular disulfide bonds within the FHD, but it does not contain two other 
      cysteines that are found within the FHD of angiopoietins 1, 2, and 4. ANGPTL3
      also does not contain the characteristic calcium binding motif found in the other
      angiopoietins. By radiation hybrid mapping and the use of surrounding genes,
      human ANGPTL3 maps to the 1p31 region.
CI  - Copyright 1999 Academic Press.
FAU - Conklin, D
AU  - Conklin D
AD  - ZymoGenetics, Inc., 1201 Eastlake Avenue East, Seattle, Washington 98012, USA.
      conklin@zgi.com
FAU - Gilbertson, D
AU  - Gilbertson D
FAU - Taft, D W
AU  - Taft DW
FAU - Maurer, M F
AU  - Maurer MF
FAU - Whitmore, T E
AU  - Whitmore TE
FAU - Smith, D L
AU  - Smith DL
FAU - Walker, K M
AU  - Walker KM
FAU - Chen, L H
AU  - Chen LH
FAU - Wattler, S
AU  - Wattler S
FAU - Nehls, M
AU  - Nehls M
FAU - Lewis, K B
AU  - Lewis KB
LA  - eng
SI  - GENBANK/AF152562
SI  - GENBANK/AF162224
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (ANGPT1 protein, human)
RN  - 0 (Angiopoietin-1)
RN  - 0 (Angiopoietin-2)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Angiopoietins)
RN  - 0 (Angpt1 protein, mouse)
RN  - 0 (Angptl3 protein, mouse)
RN  - 0 (Growth Substances)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (angiopoietin 4)
SB  - IM
MH  - Amino Acid Motifs/genetics
MH  - Amino Acid Sequence
MH  - Angiopoietin-1
MH  - Angiopoietin-2
MH  - Angiopoietin-like Proteins
MH  - *Angiopoietins
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - Blotting, Northern
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Glycosylation
MH  - Growth Substances/biosynthesis/*genetics
MH  - Humans
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Liver/*metabolism
MH  - Membrane Glycoproteins/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Physical Chromosome Mapping
MH  - Proteins/*genetics
MH  - RNA, Messenger/biosynthesis
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 2000/01/25 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
AID - 10.1006/geno.1999.6041 [doi]
AID - S0888-7543(99)96041-X [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 15;62(3):477-82. doi: 10.1006/geno.1999.6041.