PMID- 10644441
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20191210
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 3
DP  - 1999 Dec 15
TI  - Genetic, physical, and transcript map of the fld region on mouse chromosome 12.
PG  - 436-44
AB  - The fatty liver dystrophy (fld) mutation is manifested in abnormalities of lipid 
      and glucose metabolism and peripheral neuropathy. To identify the gene affected
      by this mutation, we generated a genetic map of the fld region on chromosome 12
      by the analysis of F2 offspring from an intersubspecific cross between strains
      BALB/cByJ-fld and CAST/EiJ. The results localize fld to the 0.42-cM interval
      between the microsatellite markers D12Mit170 and D12Mit184. A contig of YACs and 
      BACs covering the nonrecombinant genomic region has been constructed and used for
      the identification of genes. Expressed sequence tag mapping and exon trapping
      identified three transcripts within the critical interval: Ctla2b, which encodes 
      a cysteine protease inhibitor, and mouse homologs of KIAA0188 and KIAA0575, two
      long human transcripts of unknown function. Expression analysis revealed that
      Kiaa0188 is expressed in wildtype but not in fld liver, implicating this gene as 
      a candidate for harboring the fld mutation.
CI  - Copyright 1999 Academic Press.
FAU - Peterfy, M
AU  - Peterfy M
AD  - Department of Medicine, University of California at Los Angeles, Los Angeles,
      California 90095, USA.
FAU - Phan, J
AU  - Phan J
FAU - Oswell, G M
AU  - Oswell GM
FAU - Xu, P
AU  - Xu P
FAU - Reue, K
AU  - Reue K
LA  - eng
SI  - GENBANK/AF180470
SI  - GENBANK/AF180471
GR  - HL28481/HL/NHLBI NIH HHS/United States
GR  - HL58627/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
RN  - 0 (KIAA0575 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - EC 3.1.3.4 (LPIN1 protein, human)
RN  - EC 3.1.3.4 (Lpin1 protein, mouse)
RN  - EC 3.1.3.4 (Phosphatidate Phosphatase)
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - Chromosomes/*genetics
MH  - Cloning, Molecular
MH  - Contig Mapping
MH  - Crosses, Genetic
MH  - Exons
MH  - Fatty Liver/*genetics
MH  - Female
MH  - Gene Expression
MH  - Genetic Markers
MH  - Male
MH  - Membrane Proteins
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microsatellite Repeats
MH  - Molecular Sequence Data
MH  - *Nuclear Proteins
MH  - Phosphatidate Phosphatase
MH  - Proteins/*genetics
MH  - Sequence Tagged Sites
EDAT- 2000/01/25 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
AID - 10.1006/geno.1999.6023 [doi]
AID - S0888-7543(99)96023-8 [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 15;62(3):436-44. doi: 10.1006/geno.1999.6023.