PMID- 10644439
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20131121
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 3
DP  - 1999 Dec 15
TI  - Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane
      leucine-rich repeat proteins.
PG  - 417-26
AB  - FLRT1, FLRT2, and FLRT3 comprise a novel gene family isolated in a screen for
      extracellular matrix proteins expressed in muscle. The three genes encode
      putative type I transmembrane proteins, each containing 10 leucine-rich repeats
      flanked by N-terminal and C-terminal cysteine-rich regions, a
      fibronectin/collagen-like domain, and an intracellular tail. FLRT1 is expressed
      in kidney and brain, FLRT2 is expressed in pancreas, skeletal muscle, brain, and 
      heart, and FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, 
      liver, placenta, and heart. FLRT1 localized to 11q12-q13, FLRT2 to 14q24-q32, and
      FLRT3 to 20p11. When expressed in SF9 and COS-1 cells, FLRT1 and FLRT2 migrate as
      90- and 85-kDa proteins, respectively, and both are glycosylated. Given the
      overall structure of the three proteins, a function in cell adhesion and/or
      receptor signaling is predicted.
CI  - Copyright 1999 Academic Press.
FAU - Lacy, S E
AU  - Lacy SE
AD  - Howard Hughes Medical Institute, Division of Genetics, Children's Hospital and
      Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
FAU - Bonnemann, C G
AU  - Bonnemann CG
FAU - Buzney, E A
AU  - Buzney EA
FAU - Kunkel, L M
AU  - Kunkel LM
LA  - eng
SI  - GENBANK/AF169675
SI  - GENBANK/AF169676
SI  - GENBANK/AF169677
GR  - P30-HD18655/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (FLRT1 protein, human)
RN  - 0 (FLRT2 protein, human)
RN  - 0 (FLRT3 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - GMW67QNF9C (Leucine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 20/genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/analysis
MH  - Gene Expression
MH  - Humans
MH  - Leucine/*genetics
MH  - Membrane Proteins/chemistry/*genetics/*isolation & purification
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Muscle, Skeletal/metabolism
MH  - Organ Specificity
MH  - Protein Structure, Tertiary/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Repetitive Sequences, Amino Acid/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 2000/01/25 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
AID - 10.1006/geno.1999.6033 [doi]
AID - S0888-7543(99)96033-0 [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 15;62(3):417-26. doi: 10.1006/geno.1999.6033.