PMID- 10644438
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20191210
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 3
DP  - 1999 Dec 15
TI  - Molecular cloning, chromosomal mapping, and developmental expression of a novel
      protein tyrosine phosphatase-like gene.
PG  - 406-16
AB  - Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of
      phosphotyrosine. PTPs are known to be involved in many signal transduction
      pathways leading to cell growth, differentiation, and oncogenic transformation.
      We have cloned a new family of novel protein tyrosine phosphatase-like genes, the
      Ptpl (protein tyrosine phosphatase-like; proline instead of catalytic arginine)
      gene family. This gene family is composed of at least three members, and we
      describe here the developmental expression pattern and chromosomal location for
      one of these genes, Ptpla. In situ hybridization studies revealed that Ptpla
      expression was first detected at embryonic day 8.5 in muscle progenitors and
      later in differentiated muscle types: in the developing heart, throughout the
      liver and lungs, and in a number of neural crest derivatives including the dorsal
      root and trigeminal ganglia. Postnatally Ptpla was expressed in a number of adult
      tissues including cardiac and skeletal muscle, liver, testis, and kidney. The
      early expression pattern of this gene and its persistent expression in adult
      tissues suggest that it may have an important role in the development,
      differentiation, and maintenance of a number of different tissue types. The human
      homologue of Ptpla (PTPLA) was cloned and shown to map to 10p13-p14.
CI  - Copyright 1999 Academic Press.
FAU - Uwanogho, D A
AU  - Uwanogho DA
AD  - Department of Craniofacial Development, Kings College at Guy's Hospital, London.
FAU - Hardcastle, Z
AU  - Hardcastle Z
FAU - Balogh, P
AU  - Balogh P
FAU - Mirza, G
AU  - Mirza G
FAU - Thornburg, K L
AU  - Thornburg KL
FAU - Ragoussis, J
AU  - Ragoussis J
FAU - Sharpe, P T
AU  - Sharpe PT
LA  - eng
SI  - GENBANK/AF114493
SI  - GENBANK/AF114494
SI  - GENBANK/AF162706
SI  - GENBANK/AF162707
SI  - GENBANK/AF169286
GR  - G9800001/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - EC 3.1.3.48 (HACD1 protein, human)
RN  - EC 3.1.3.48 (Hacd1 protein, mouse)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans
MH  - Chick Embryo
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 10/genetics
MH  - *Cloning, Molecular
MH  - DiGeorge Syndrome/genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Heart/embryology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Liver/embryology/enzymology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Muscle, Skeletal/embryology/enzymology
MH  - Myocardium/enzymology
MH  - Organ Specificity
MH  - Protein Tyrosine Phosphatases/*biosynthesis/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Sheep
EDAT- 2000/01/25 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
AID - 10.1006/geno.1999.5950 [doi]
AID - S0888-7543(99)95950-5 [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 15;62(3):406-16. doi: 10.1006/geno.1999.5950.