PMID- 10644437
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20190402
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 3
DP  - 1999 Dec 15
TI  - USP25, a novel gene encoding a deubiquitinating enzyme, is located in the
      gene-poor region 21q11.2.
PG  - 395-405
AB  - We have identified a new gene, USP25, spanning over 150 kb at 21q11. 2, one of
      the lowest gene-density regions of the human genome. USP25 is made up of 25 exons
      and encodes a 1087-aa protein. Database comparisons reveal high homology with
      members of the ubiquitin protease family (UBP). Basal expression was observed in 
      all human tissues tested, and two main transcripts were identified. The
      homologous murine gene has also been characterized. In situ hybridization in
      mouse embryonic brains showed a clear correlation of expression with
      proliferative neuroepithelial cells and postmitotic neurons. Moreover, high
      expression was observed in adult mouse testis. UBPs belong to a complex family of
      deubiquitinating enzymes that specifically cleave ubiquitin conjugates on a great
      variety of substrates. These enzymes have an essential role in protein
      degradation via the 26S proteasome and thus regulate many cellular pathways. An
      increase in USP25 gene dosage in Down syndrome patients could seriously disturb
      the balance between ubiquitinated and deubiquitinated substrates.
CI  - Copyright 1999 Academic Press.
FAU - Valero, R
AU  - Valero R
AD  - Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Avinguda
      Diagonal 645, Barcelona, 08028, Spain.
FAU - Marfany, G
AU  - Marfany G
FAU - Gonzalez-Angulo, O
AU  - Gonzalez-Angulo O
FAU - Gonzalez-Gonzalez, G
AU  - Gonzalez-Gonzalez G
FAU - Puelles, L
AU  - Puelles L
FAU - Gonzalez-Duarte, R
AU  - Gonzalez-Duarte R
LA  - eng
SI  - GENBANK/AF170562
SI  - GENBANK/AF170563
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (USP25 protein, human)
RN  - 0 (Ubiquitins)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Brain/embryology/enzymology
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - DNA, Complementary/analysis
MH  - Down Syndrome/genetics
MH  - Endopeptidases/*genetics/metabolism
MH  - Exons/genetics
MH  - Gene Expression
MH  - Humans
MH  - In Situ Hybridization
MH  - Introns/genetics
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/enzymology
MH  - Organ Specificity
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Testis/enzymology
MH  - Ubiquitin Thiolesterase
MH  - Ubiquitins/*metabolism
EDAT- 2000/01/25 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
AID - 10.1006/geno.1999.6025 [doi]
AID - S0888-7543(99)96025-1 [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 15;62(3):395-405. doi: 10.1006/geno.1999.6025.