PMID- 10644038
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20190623
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 59
IP  - 4
DP  - 2000 Feb 15
TI  - Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural 
      killer cells.
PG  - 317-20
AB  - Granulysin is a novel antimicrobial protein produced by human cytolytic T
      lymphocytes and natural killer cells. It is active against a broad range of
      microbes, including Gram-positive and Gram-negative bacteria, fungi, and
      parasites. The fact that it kills Mycobacterium tuberculosis is particularly
      important, since the current vaccine (Bacille Calmette-Guerin, BCG) is of limited
      efficacy and antibiotic resistance is increasing. Although functionally related
      to other antibacterial peptides, defensins and magainins, granulysin is
      structurally distinct. Like porcine NK lysin and amoebapores made by Entamoeba
      histolytica, granulysin is related to saposins, small lipid-associated proteins
      present in the central nervous system. The identification of this novel molecule 
      indicates a broader and perhaps more significant role for T lymphocytes in both
      innate and acquired antimicrobial defenses.
FAU - Krensky, A M
AU  - Krensky AM
AD  - Department of Pediatrics, Stanford University School of Medicine, CA 94305-5208, 
      USA. mn.aln@forsythe.stanford.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (GNLY protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/*pharmacology
MH  - Antigens, Differentiation, T-Lymphocyte/chemistry/*pharmacology
MH  - Apoptosis/drug effects
MH  - Humans
MH  - Killer Cells, Natural/*metabolism
MH  - Molecular Sequence Data
MH  - Mycobacterium tuberculosis/*drug effects
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes, Cytotoxic/*metabolism
RF  - 21
EDAT- 2000/01/22 00:00
MHDA- 2000/01/22 00:01
CRDT- 2000/01/22 00:00
PHST- 2000/01/22 00:00 [pubmed]
PHST- 2000/01/22 00:01 [medline]
PHST- 2000/01/22 00:00 [entrez]
AID - S0006-2952(99)00177-X [pii]
AID - 10.1016/s0006-2952(99)00177-x [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2000 Feb 15;59(4):317-20. doi: 10.1016/s0006-2952(99)00177-x.