PMID- 10640832
OWN - NLM
STAT- MEDLINE
DCOM- 20000516
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 87
IP  - 1-2
DP  - 1999
TI  - The human gene for the poly(A)-specific ribonuclease (PARN) maps to 16p13 and has
      a truncated copy in the Prader-Willi/Angelman syndrome region on 15q11-->q13.
PG  - 125-31
AB  - The deadenylation nuclease or poly(A)-specific ribonuclease (PARN) is a 3'
      exonuclease, which degrades the poly(A)-tail of eukaryotic mRNA molecules. By DNA
      sequence analysis of cDNA and genomic clones, fluorescence in situ hybridization,
      and reverse transcriptase-PCR, we have determined that the active human PARN gene
      is located in 16p13 and that a truncated copy lacking the 5' end is located in
      15q11. The truncated gene maps close to a copy of the D15F37 gene family at the
      proximal Prader-Willi/Angelman (PWS/AS) deletion breakpoint region. Other copies 
      of the F37 gene family are located at the distal PWS/AS deletion breakpoint
      region and on 16p11.2. Although PARN and F37 gene sequences are present on 15q
      and 16p, our data suggest that the synteny of these loci is the result of
      independent genetic events.
CI  - Copyright 1999 S. Karger AG, Basel
FAU - Buiting, K
AU  - Buiting K
AD  - Institut fur Humangenetik, Universitatsklinikum Essen, Germany.
      karin.buiting@uni-essen.de
FAU - Korner, C
AU  - Korner C
FAU - Ulrich, B
AU  - Ulrich B
FAU - Wahle, E
AU  - Wahle E
FAU - Horsthemke, B
AU  - Horsthemke B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (3' Untranslated Regions)
RN  - 0 (RNA, Messenger)
RN  - EC 3.1.- (Exoribonucleases)
RN  - EC 3.1.13.4 (poly(A)-specific ribonuclease)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Alleles
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Chromosome Breakage/genetics
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Exoribonucleases/*genetics
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes
MH  - Male
MH  - Molecular Sequence Data
MH  - Multigene Family/genetics
MH  - *Physical Chromosome Mapping
MH  - Prader-Willi Syndrome/*genetics
MH  - RNA, Messenger/analysis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Deletion/*genetics
EDAT- 2000/01/21 09:00
MHDA- 2000/05/20 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/05/20 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - 15378 [pii]
AID - 10.1159/000015378 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;87(1-2):125-31. doi: 10.1159/000015378.