PMID- 10640816
OWN - NLM
STAT- MEDLINE
DCOM- 20000516
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 87
IP  - 1-2
DP  - 1999
TI  - Identification, characterization, and mapping of a mouse homolog of the gene
      mutated in Nijmegen breakage syndrome.
PG  - 80-4
AB  - The rare autosomal recessive disorder Nijmegen breakage syndrome (NBS) results
      from mutations in the NBS1 gene on human chromosome 8q21. A mouse homolog of the 
      NBS1 gene was isolated and its nucleotide sequence determined. Somatic cell
      hybrid analysis and fluorescence in situ hybridization were used to map this
      gene, Nbn, to mouse chromosome band 4A. Northern blotting revealed comparable
      levels of Nbn transcripts in most tissues in the mouse. However, transcripts were
      elevated 10-20 fold in the testes, consistent with a possible role for the
      product of the Nbn gene in meiotic recombination.
CI  - Copyright 1999 S. Karger AG, Basel
FAU - Vissinga, C S
AU  - Vissinga CS
AD  - Molecular Genetics Program, Virginia Mason Research Center, and Department of
      Immunology, University of Washington School of Medicine, Seattle, WA 98101, USA.
FAU - Yeo, T C
AU  - Yeo TC
FAU - Woessner, J
AU  - Woessner J
FAU - Massa, H F
AU  - Massa HF
FAU - Wilson, R K
AU  - Wilson RK
FAU - Trask, B J
AU  - Trask BJ
FAU - Concannon, P
AU  - Concannon P
LA  - eng
SI  - GENBANK/AF076687
GR  - R01 CA057569/CA/NCI NIH HHS/United States
GR  - CA57569/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (NBN protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Cycle Proteins/chemistry/*genetics
MH  - Cloning, Molecular
MH  - Expressed Sequence Tags
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mutation/*genetics
MH  - *Nuclear Proteins
MH  - Organ Specificity
MH  - *Physical Chromosome Mapping
MH  - RNA, Messenger/analysis/genetics
MH  - Sequence Alignment
MH  - *Sequence Homology, Nucleic Acid
MH  - Syndrome
MH  - Testis/metabolism
EDAT- 2000/01/21 09:00
MHDA- 2000/05/20 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/05/20 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - 15396 [pii]
AID - 10.1159/000015396 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;87(1-2):80-4. doi: 10.1159/000015396.