PMID- 10640815
OWN - NLM
STAT- MEDLINE
DCOM- 20000516
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 87
IP  - 1-2
DP  - 1999
TI  - Characterization and chromosome location of the mouse link protein gene (Crtl1).
PG  - 75-9
AB  - Link protein (LP) plays an essential role in endochondral bone formation by
      stabilizing the supramolecular assemblies of aggrecan and hyaluronan. We have
      isolated and characterized the mouse link protein gene (Crtl1). It is longer than
      40 kb and transcribed from two alternative promoters, leading to heterogenous
      mRNAs between 5.3 and 1.3 kb in size. Apart from the coding sequence, the 5'
      flanking region is also highly conserved in mammals. Immunostaining revealed high
      levels of LP expression in the cartilaginous primordia of skeletal elements and
      low levels in other tissues. Using single-strand conformation polymorphism
      analysis, Crtl1 was assigned to mouse chromosome 13, tightly linked to Dhfr.
CI  - Copyright 1999 S. Karger AG, Basel
FAU - Deak, F
AU  - Deak F
AD  - Institute of Biochemistry, Biological Research Center of the Hungarian Academy of
      Sciences, Szeged, Hungary.
FAU - Mates, L
AU  - Mates L
FAU - Krysan, K
AU  - Krysan K
FAU - Liu, Z
AU  - Liu Z
FAU - Szabo, P E
AU  - Szabo PE
FAU - Mann, J R
AU  - Mann JR
FAU - Beier, D R
AU  - Beier DR
FAU - Kiss, I
AU  - Kiss I
LA  - eng
SI  - GENBANK/AF137274
SI  - GENBANK/AF137275
SI  - GENBANK/AF137276
SI  - GENBANK/AF137277
SI  - GENBANK/AF137278
SI  - GENBANK/AF139572
GR  - DK45639/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proteoglycans)
RN  - 0 (RNA, Messenger)
RN  - 0 (link protein)
RN  - EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Western
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - Conserved Sequence/genetics
MH  - Embryo, Mammalian/metabolism
MH  - Exons/genetics
MH  - *Extracellular Matrix Proteins
MH  - Gene Expression Regulation, Developmental
MH  - Genetic Linkage/genetics
MH  - Humans
MH  - Introns/genetics
MH  - Mice
MH  - Microsatellite Repeats/genetics
MH  - Molecular Sequence Data
MH  - Polymorphism, Single-Stranded Conformational
MH  - Promoter Regions, Genetic/genetics
MH  - Proteins/chemistry/*genetics/metabolism
MH  - *Proteoglycans
MH  - RNA, Messenger/analysis/genetics
MH  - Sequence Alignment
MH  - Tetrahydrofolate Dehydrogenase/genetics
EDAT- 2000/01/21 09:00
MHDA- 2000/05/20 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/05/20 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - 15395 [pii]
AID - 10.1159/000015395 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;87(1-2):75-9. doi: 10.1159/000015395.