PMID- 10640718
OWN - NLM
STAT- MEDLINE
DCOM- 20000427
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 90
IP  - 2
DP  - 2000 Feb
TI  - Localized expression of the Drosophila gene Dxl6, a novel member of the
      serine/arginine rich (SR) family of splicing factors.
PG  - 309-12
AB  - Members of the highly conserved family of serine/arginine rich (SR) splicing
      factors play an essential role in the recognition of the exonic splicing
      enhancers that control the choice of splice sites in primary transcripts. Here,
      we report the cloning and the expression pattern of Dxl6, a novel Drosophila
      member of this protein family. Dxl6 is located on the second chromosome in a
      position next to hrp48 and Dwee1. Its intron contains Dnop5, a small nucleolar
      ribonucleoprotein (snoRNP) which is essential for rRNA-processing. During
      oogenesis, Dxl6 transcripts are expressed in nurse cells. Transcripts are
      transported into the oocyte and maintained in a ubiquitous pattern in the egg and
      early embryo. Zygotic Dxl6 transcripts accumulate in the neuroectodermal region
      of the gastrulating embryo and become highly enriched in the central nervous
      system (CNS) and brain of embryos. During larval stages, Dxl6 transcripts are
      detected in distinct patterns in the developing imaginal discs.
FAU - Vorbruggen, G
AU  - Vorbruggen G
AD  - Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare
      Entwicklungsbiologie, Am Fassberg 11, D-37077, Gottingen, Germany.
FAU - Onel, S
AU  - Onel S
FAU - Jackle, H
AU  - Jackle H
LA  - eng
SI  - GENBANK/AC004277
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Insect Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SRSF3 protein, human)
RN  - 0 (Srsf3 protein, mouse)
RN  - 170974-22-8 (Serine-Arginine Splicing Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Drosophila melanogaster/embryology/*genetics
MH  - Gene Expression
MH  - Genes, Insect
MH  - Humans
MH  - Insect Proteins/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - *RNA Splicing
MH  - RNA-Binding Proteins/*genetics
MH  - Serine-Arginine Splicing Factors
MH  - Tissue Distribution
EDAT- 2000/01/21 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - S0925477399002506 [pii]
AID - 10.1016/s0925-4773(99)00250-6 [doi]
PST - ppublish
SO  - Mech Dev. 2000 Feb;90(2):309-12. doi: 10.1016/s0925-4773(99)00250-6.