PMID- 10639155
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 97
IP  - 2
DP  - 2000 Jan 18
TI  - Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17
      cytokine family.
PG  - 773-8
AB  - IL-17 is a T cell-derived cytokine that may play an important role in the
      initiation or maintenance of the proinflammatory response. Whereas expression of 
      IL-17 is restricted to activated T cells, the IL-17 receptor is found to be
      widely expressed, a finding consistent with the pleiotropic activities of IL-17. 
      We have cloned and expressed two novel human cytokines, IL-17B and IL-17C, that
      are related to IL-17 ( approximately 27% amino acid identity). IL-17B mRNA is
      expressed in adult pancreas, small intestine, and stomach, whereas IL-17C mRNA is
      not detected by RNA blot hybridization of several adult tissues. No expression of
      IL-17B or IL-17C mRNA is found in activated T cells. In a survey of cytokine
      induction, IL-17B and IL-17C stimulate the release of tumor necrosis factor alpha
      and IL-1beta from the monocytic cell line, THP-1, whereas IL-17 has only a weak
      effect in this system. No induction of IL-1alpha, IL-6, IFN-gamma, or granulocyte
      colony-stimulating factor is found in THP-1 cells. Fluorescence-activated cell
      sorter analysis shows that IL-17B and IL-17C bind to THP-1 cells. Conversely,
      IL-17B and IL-17C are not active in an IL-17 assay or the stimulation of IL-6
      release from human fibroblasts and do not bind to the human IL-17 receptor
      extracellular domain. These data show that there is a family of IL-17-related
      cytokines differing in patterns of expression and proinflammatory responses that 
      may be transduced through a cognate set of cell surface receptors.
FAU - Li, H
AU  - Li H
AD  - Department of Molecular Biology, Genentech, Inc., 1 DNA Way, South San Francisco,
      CA 94080, USA.
FAU - Chen, J
AU  - Chen J
FAU - Huang, A
AU  - Huang A
FAU - Stinson, J
AU  - Stinson J
FAU - Heldens, S
AU  - Heldens S
FAU - Foster, J
AU  - Foster J
FAU - Dowd, P
AU  - Dowd P
FAU - Gurney, A L
AU  - Gurney AL
FAU - Wood, W I
AU  - Wood WI
LA  - eng
SI  - GENBANK/AF152098
SI  - GENBANK/AF152099
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Cytokines)
RN  - 0 (DNA, Complementary)
RN  - 0 (IL17RA protein, human)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-17)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-17)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 16/genetics
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Cloning, Molecular
MH  - Cricetinae
MH  - Cytokines/genetics
MH  - DNA, Complementary/chemistry/genetics
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Interleukin-1/metabolism
MH  - Interleukin-17/*genetics/metabolism/pharmacology
MH  - Male
MH  - Molecular Sequence Data
MH  - Monocytes/drug effects/metabolism
MH  - Protein Binding
MH  - Protein Isoforms/genetics/metabolism/pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Interleukin/metabolism
MH  - Receptors, Interleukin-17
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Tumor Necrosis Factor-alpha/metabolism
PMC - PMC15406
EDAT- 2000/01/19 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/19 09:00
PHST- 2000/01/19 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/19 09:00 [entrez]
AID - 10.1073/pnas.97.2.773 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):773-8. doi: 10.1073/pnas.97.2.773.