PMID- 10637508
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20190816
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 56
DP  - 1999 Dec 23
TI  - MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 
      and is amplified in solid tumor cell lines.
PG  - 7975-84
AB  - The Mixed Lineage Leukemia (MLL) gene is commonly involved in translocations in
      infantile leukemia and is amplified in some cases of adult myeloid leukemia. A
      homolog of MLL denoted MLL2, which represents the second human homolog of the
      Drosophila trithorax gene, was characterized by assembling ESTs, the KIAA0304
      cDNA clone, RT - PCR fragments and a new clone isolated from a cDNA phage library
      and compared to the available genomic sequence. The MLL2 gene maps to 19q13.1, a 
      region of frequent rearrangement or amplification in solid tumors. MLL2 consists 
      of an 8.5 - 9 kb transcript and spans 20 kb of genomic DNA. The predicted MLL2
      protein possesses all of the major domains defined in MLL and the two genes have 
      a similar genomic structure. We find that MLL2 is amplified in two of 14
      pancreatic carcinoma cell lines and one of five glioblastoma cell lines and is a 
      likely critical gene in 19q13.1 amplifications. It is also a candidate for
      chromosomal rearrangements involving this chromosome locus. MLL2 is one
      additional mammalian trithorax-group gene with involvement in human cancer.
FAU - Huntsman, D G
AU  - Huntsman DG
AD  - CRC Department of Oncology and Cambridge Institute for Medical Research,
      University of Cambridge, Wellcome Trust-MRC Building, Addenbrooke's Hospital,
      Cambridge CB2 2XY, UK.
FAU - Chin, S F
AU  - Chin SF
FAU - Muleris, M
AU  - Muleris M
FAU - Batley, S J
AU  - Batley SJ
FAU - Collins, V P
AU  - Collins VP
FAU - Wiedemann, L M
AU  - Wiedemann LM
FAU - Aparicio, S
AU  - Aparicio S
FAU - Caldas, C
AU  - Caldas C
LA  - eng
SI  - GENBANK/AJ007041
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (KMT2D protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Trl protein, Drosophila)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - DNA-Binding Proteins/chemistry/*genetics
MH  - Drosophila/genetics
MH  - *Drosophila Proteins
MH  - Exons
MH  - Glioblastoma/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/genetics
MH  - Pancreatic Neoplasms/*genetics
MH  - Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - *Transcription Factors
MH  - Transcription, Genetic
MH  - Tumor Cells, Cultured
EDAT- 2000/01/19 00:00
MHDA- 2000/01/19 00:01
CRDT- 2000/01/19 00:00
PHST- 2000/01/19 00:00 [pubmed]
PHST- 2000/01/19 00:01 [medline]
PHST- 2000/01/19 00:00 [entrez]
AID - 10.1038/sj.onc.1203291 [doi]
PST - ppublish
SO  - Oncogene. 1999 Dec 23;18(56):7975-84. doi: 10.1038/sj.onc.1203291.