PMID- 10637174
OWN - NLM
STAT- MEDLINE
DCOM- 20000421
LR  - 20061115
IS  - 0022-0949 (Print)
IS  - 0022-0949 (Linking)
VI  - 203
IP  - Pt 3
DP  - 2000 Feb
TI  - Identification of a ubiquitous family of membrane proteins and their expression
      in mouse brain.
PG  - 447-57
AB  - A family of genes encoding membrane proteins with a unique structure has been
      identified in DNA and cDNA clones of various eukaryotes ranging from yeast to
      human. The nucleotide sequences of three novel cDNAs from Drosophila melanogaster
      and mouse were determined. The amino acid sequences of the two mouse proteins
      have human homologs. The gene (TMS1) encoding the yeast member of this family was
      disrupted, and the resulting mutant showed no significant phenotype under several
      stress conditions. The expression of the mouse genes TMS-1 and TMS-2 was examined
      by in situ hybridization of sections from brain, liver, kidney, heart and testis 
      of an adult mouse as well as in a 1-day-old whole mouse. While the expression of 
      TMS-2 was found to be restricted to the central nervous system, TMS-1 was also
      expressed in kidney and testis. The expression of TMS-1 and TMS-2 in the brain
      overlapped and was localized to areas associated with glutamatergic excitatory
      neurons, such as the hippocampus and cerebral cortex. High-magnification analysis
      indicated that both mRNAs are expressed in neurons. Semiquantitative analysis of 
      mRNA expression was performed in various parts of the brain. The conservation,
      unique structure and localization in the mammalian brain of this novel protein
      family suggest an important biological role.
FAU - Grossman, T R
AU  - Grossman TR
AD  - Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv
      University, Israel.
FAU - Luque, J M
AU  - Luque JM
FAU - Nelson, N
AU  - Nelson N
LA  - eng
SI  - GENBANK/AF181684
SI  - GENBANK/AF181685
SI  - GENBANK/AF181686
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Exp Biol
JT  - The Journal of experimental biology
JID - 0243705
RN  - 0 (Fungal Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Schizosaccharomyces pombe Proteins)
RN  - 0 (Tde2 protein, mouse)
RN  - EC 1.1.1.14 (L-Iditol 2-Dehydrogenase)
RN  - EC 1.1.1.14 (TMS1 protein, S pombe)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/anatomy & histology/*metabolism
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Drosophila/genetics
MH  - Expressed Sequence Tags
MH  - Fluorescent Antibody Technique
MH  - Fungal Proteins/*genetics/metabolism
MH  - Humans
MH  - In Situ Hybridization
MH  - *L-Iditol 2-Dehydrogenase
MH  - Membrane Proteins/*genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Protein Structure, Tertiary
MH  - Saccharomyces cerevisiae/genetics
MH  - *Schizosaccharomyces pombe Proteins
MH  - Sequence Alignment
EDAT- 2000/01/19 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/01/19 09:00
PHST- 2000/01/19 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/01/19 09:00 [entrez]
PST - ppublish
SO  - J Exp Biol. 2000 Feb;203(Pt 3):447-57.