PMID- 10633034
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20190709
IS  - 0022-2623 (Print)
IS  - 0022-2623 (Linking)
VI  - 43
IP  - 1
DP  - 2000 Jan 13
TI  - Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic
      carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.
PG  - 19-21
FAU - Biggadike, K
AU  - Biggadike K
AD  - Medicinal Chemistry, Enzyme Pharmacology, Biomet Doscovery and Potein Science
      Units, Glaxo Wellcome Research and Development, Medicines Research Centre,
      Hertsfordshire, UK. kb0903@ggr.co.uk
FAU - Angell, R M
AU  - Angell RM
FAU - Burgess, C M
AU  - Burgess CM
FAU - Farrell, R M
AU  - Farrell RM
FAU - Hancock, A P
AU  - Hancock AP
FAU - Harker, A J
AU  - Harker AJ
FAU - Irving, W R
AU  - Irving WR
FAU - Ioannou, C
AU  - Ioannou C
FAU - Procopiou, P A
AU  - Procopiou PA
FAU - Shaw, R E
AU  - Shaw RE
FAU - Solanke, Y E
AU  - Solanke YE
FAU - Singh, O M
AU  - Singh OM
FAU - Snowden, M A
AU  - Snowden MA
FAU - Stubbs, R J
AU  - Stubbs RJ
FAU - Walton, S
AU  - Walton S
FAU - Weston, H E
AU  - Weston HE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Carbonates)
RN  - 0 (Glucocorticoids)
RN  - 0 (Lactones)
RN  - 0 (Prodrugs)
RN  - EC 3.1.- (Esterases)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
SB  - IM
MH  - Aryldialkylphosphatase
MH  - Carbonates/blood/*chemistry
MH  - Esterases/*blood
MH  - Glucocorticoids/blood/*chemistry
MH  - Humans
MH  - Hydrolysis
MH  - In Vitro Techniques
MH  - Lactones/blood/*chemistry
MH  - Lung/metabolism
MH  - Prodrugs/*chemistry/metabolism
MH  - Stereoisomerism
MH  - Subcellular Fractions/metabolism
EDAT- 2000/01/14 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/14 09:00
PHST- 2000/01/14 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/14 09:00 [entrez]
AID - 10.1021/jm990436t [doi]
PST - ppublish
SO  - J Med Chem. 2000 Jan 13;43(1):19-21. doi: 10.1021/jm990436t.