PMID- 10632589
OWN - NLM
STAT- MEDLINE
DCOM- 20000209
LR  - 20081121
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 2
DP  - 2000 Jan 15
TI  - A novel human opsin in the inner retina.
PG  - 600-5
AB  - Here we report the identification of a novel human opsin, melanopsin, that is
      expressed in cells of the mammalian inner retina. The human melanopsin gene
      consists of 10 exons and is mapped to chromosome 10q22. This chromosomal
      localization and gene structure differs significantly from that of other human
      opsins that typically have four to seven exons. A survey of 26 anatomical sites
      indicates that, in humans, melanopsin is expressed only in the eye. In situ
      hybridization histochemistry shows that melanopsin expression is restricted to
      cells within the ganglion and amacrine cell layers of the primate and murine
      retinas. Notably, expression is not observed in retinal photoreceptor cells, the 
      opsin-containing cells of the outer retina that initiate vision. The unique inner
      retinal localization of melanopsin suggests that it is not involved in image
      formation but rather may mediate nonvisual photoreceptive tasks, such as the
      regulation of circadian rhythms and the acute suppression of pineal melatonin.
      The anatomical distribution of melanopsin-positive retinal cells is similar to
      the pattern of cells known to project from the retina to the suprachiasmatic
      nuclei of the hypothalamus, a primary circadian pacemaker.
FAU - Provencio, I
AU  - Provencio I
AD  - Department of Anatomy and Cell Biology, Uniformed Services University of the
      Health Sciences, Bethesda, Maryland 20814, USA.
FAU - Rodriguez, I R
AU  - Rodriguez IR
FAU - Jiang, G
AU  - Jiang G
FAU - Hayes, W P
AU  - Hayes WP
FAU - Moreira, E F
AU  - Moreira EF
FAU - Rollag, M D
AU  - Rollag MD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (Rod Opsins)
RN  - 0 (melanopsin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 10
MH  - Cloning, Molecular
MH  - Exons
MH  - Humans
MH  - In Situ Hybridization
MH  - Macaca mulatta
MH  - Mice
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Primates
MH  - Retina/cytology/*metabolism
MH  - Retinal Ganglion Cells/cytology/metabolism
MH  - Rod Opsins/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 2000/01/13 00:00
MHDA- 2000/01/13 00:01
CRDT- 2000/01/13 00:00
PHST- 2000/01/13 00:00 [pubmed]
PHST- 2000/01/13 00:01 [medline]
PHST- 2000/01/13 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 2000 Jan 15;20(2):600-5.